Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Lung surgery ventilation showdown: high vs low pressure in 2,200 patients

NCT ID NCT02963025

Knowledge-focused Sponsor: Technische Universität Dresden Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 2,200 adults having lung surgery where one lung is deflated during the procedure. Doctors tested two ways of using the breathing machine: one with higher pressure and periodic deep breaths, the other with lower pressure and no deep breaths. The goal was to see which method better prevents lung problems after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

2,200 people

The number who actually took part.

Started

Jan 2017

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient scheduled for open thoracic or video-assisted thoracoscopic surgery under general anesthesia requiring OLV (no emergency surgery) * BMI \< 35 kg/m2 * age ≥ 18 years * expected duration of surgery \> 60 min * planned lung separation with double lumen tube (DLT, not for study purpose only) * most of ventilation time during surgery expected to be in OLV Exclusion Criteria: * COPD GOLD grades III and IV, lung fibrosis, documented bullae, severe emphysema, pneumothorax * uncontrolled asthma * Heart failure NYHA Grade 3 and 4, Coronary Heart Disease CCS Grade 3 and 4 * previous lung surgery * documented pulmonary arterial hypertension \>25mmHg MPAP at rest or \> 40 mmHg syst. (estimated by ultrasound) * documented or suspected neuromuscular disease (thymoma, myasthenia, myopathies, muscular dystrophies, others) * planned mechanical ventilation after surgery * bilateral procedures * lung separation with other method than DLT (e.g. difficult airway, tracheostomy) * surgery in prone position * persistent hemodynamic instability, intractable shock * intracranial injury or tumor * enrollment in other interventional study or refusal of informed consent * pregnancy (excluded by anamnesis and/or laboratory analysis) * esophagectomy, pleural surgery only, sympathectomy surgery only, chest wall surgery only, mediastinal surgery only, lung transplantation * presence before induction of anaesthesia of one of the adverse events, listed as postoperative pulmonary complications (aspiration, moderate respiratory failure, infiltrates, pulmonary infection, atelectasis, cardiopulmonary edema, pleural effusion, pneumothorax, pulmonary embolism, purulent pleuritis, lung hemorrhage) * documented preoperative hypercapnia \> 45mmHg (6kPa)

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for One-lung ventilation are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

One-lung ventilation

Contacts and locations

Locations

  • AOU G.Martino

    Messina, Italy

  • Academic Medical Center Amsterdam

    Amsterdam, Netherlands

  • Acıbadem Mehmet Ali Aydınlar University

    Istanbul, Turkey (Türkiye)

  • American Hospital Tirana

    Tirana, Albania

  • Anhui Provincial Hospital, First Aff. Hospital, University of Science and Technology of China

    Hefei, China

  • Ankara Ataturk Chest Diseases And Chest Surgery Training and Research Hospital

    Ankara, Turkey (Türkiye)

  • Ankara University Medical Faculty

    Ankara, Turkey (Türkiye)

  • Arcispedale Sant'Anna

    Ferrara, Italy

  • Attikon University Hospital

    Athens, Greece

  • Azadi Heart Center, Iraq

    Duhok, Iraq

  • Celal Bayar University Medical Faculty, Dept of Anesthesiology

    Manisa, Turkey (Türkiye)

  • Cleveland Clinic, USA

    Cleveland, Ohio, United States

  • Clinical Center Nis, Clinic for anesthesia and intensive therapy

    Niš, Serbia

  • Clinics Hospital from the Botucatu Medical School, University of Sao Paulo State

    São Paulo, Brazil

  • Department of Anesthesia, College of Medicine, King Saud University Medical City, Saudi-Arabia

    Riyadh, Saudi Arabia

  • Department of Anesthesiology and Intensive Care, Dresden University of Technology

    Dresden, 01307, Germany

  • Evangelistria Medical Center, Cyprus

    Égkomi, Cyprus

  • Fachkrankenhaus Coswig

    Coswig, Germany

  • First Affiliated Hospital of Guangzhou Medical University, China

    Guangzhou, China

  • Fudan University, Shanghai Cancer Center

    Shanghai, China

  • General University Hospital

    Prague, Czechia

  • Golden Jubilee National Hospital

    Clydebank, United Kingdom

  • Hospital Clínic. Universitat de Barcelona

    Barcelona, Spain

  • Hospital General Universitario de Valencia

    Valencia, Spain

  • Hospital Universitario de La Ribera

    Valencia, Spain

  • Hospital de Amor, Barretos

    Barretos, Brazil

  • Hospital Álvaro Cunqueiro

    Vigo, Spain

  • Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico

    Tlalpan, Mexico

  • Institutul de Pneumoftiziologie Bucharest

    Bucharest, Romania

  • Insular Hospital, Gran Canaria, Spain

    Las Palmas de Gran Canaria, Spain

  • Istanbul Kartal Dr. Lutfi Kirdar Education and Research Hospital

    Istanbul, Turkey (Türkiye)

  • Istanbul University

    Istanbul, Turkey (Türkiye)

  • Juntendo University Hospital

    Tokyo, Japan

  • LMU Muenchen

    München, Germany

  • Mansoura University Hospitals, Egypt

    Al Mansurah, Egypt

  • Marmara University Medical Faculty

    Istanbul, Turkey (Türkiye)

  • Medical University of Vienna

    Vienna, Austria

  • Mersin University Medical Faculty

    Mersin, Turkey (Türkiye)

  • Military Medical Academy

    Belgrade, Serbia

  • NIHS Sheffield Clinical Research Facility

    Sheffield, United Kingdom

  • NYC Cornell Medical College

    New York, New York, United States

  • OORR Foggia, University of Foggia

    Foggia, Italy

  • Ospedale Policlinico San Martino

    Genova, Italy

  • Pamukkale University Dinizli

    Pamukkale, Turkey (Türkiye)

  • Patras University Hospital

    Pátrai, Greece

  • Pontificia Universidad Catolica de Chile

    Santiago, Chile

  • Radboud University Medical Centre Nijmegen

    Nijmegen, Netherlands

  • Riga East University Hospital, Riga, Latvia

    Riga, Latvia

  • Rijnstate Hospital

    Arnhem, Netherlands

  • Sao Paulo Hospital

    São Paulo, Brazil

  • Sotiria Chest Hospital

    Athens, Greece

  • St George's Hospital London

    London, United Kingdom

  • Taichung Veterans General Hospital

    Taichung, Taiwan

  • Tanta University Hospital

    Tanta, Egypt

  • Tufts Medical Center

    Boston, Massachusetts, United States

  • University Clinical centre of Serbia, Serbia

    Belgrade, Serbia

  • University Hospital Aachen

    Aachen, Germany

  • University Hospital Dubrava

    Zagreb, Croatia

  • University Hospital Freiburg

    Freiburg im Breisgau, Germany

  • University Hospital Goettingen, Germany

    Göttingen, Germany

  • University Hospital Magdeburg

    Magdeburg, Germany

  • University Hospital Vanvitelli

    Naples, Italy

  • University Hospital Zagreb

    Zagreb, Croatia

  • University Hospital of Dijon - François Mitterrand

    Dijon, France

  • University Hospital of Geneva

    Geneva, Switzerland

  • University Hospital of Heraklion

    Heraklion, Greece

  • University Hospital of Parma

    Parma, Italy

  • University Hospitals Bristol NHS Foundation Trust

    Bristol, United Kingdom

  • University Hospitals of Leicester

    Leicester, United Kingdom

  • University Medical Centre Ljubljana

    Ljubljana, Slovenia

  • University School of Medicine Campus Bio-Medico of Rome

    Rome, Italy

  • University of Debrecen, Department of anesthesiology and Intensive Care

    Debrecen, Hungary

  • University of Health Science, Konya City Hospital, Turkey

    Konya, Turkey (Türkiye)

  • University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Turkey

    Bakırköy, Turkey (Türkiye)

  • University of Novi Sad, Serbia

    Novi Sad, Serbia

  • University-Hospital of Udine

    Udine, Italy

  • VU medical center Amsterdam

    Amsterdam, Netherlands

  • West China Hospital Sichuan

    Sichuan, China

  • Zhongshan Hospital Fudan University

    Shanghai, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.