Plant vs. animal protein: which boosts ketogenic weight loss?
NCT ID NCT06461806
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how the source of protein in a high-protein ketogenic diet influences weight loss and inflammation in people with obesity. Sixty adults will follow a 12-week diet with either plant protein (pea/lupine) or animal protein (whey). Researchers will measure weight, body fat, and immune markers in fat tissue to see if one protein source is better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dietary supplement (pea/lupine protein powder or whey protein powder)
- What this could lead to
- If it works, this could show that the type of protein in a ketogenic diet matters for weight loss and reducing inflammation, potentially leading to better dietary recommendations.
- What could go wrong
- This is a small, early-stage study with only 60 participants, so results may not apply to everyone. It tests a dietary change, not a drug, so the effects are likely modest.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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Oct 2022
- Expected to finish
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Jan 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults between 18-60 years old * BMI: \>29.99kg/m2 Exclusion Criteria: * Any chronic metabolic conditions (e.g. CVD) * Renal impairment (creatinine clearance \<60 mL/min) * Uncontrolled hypothyroidism * Pregnant, breastfeeding, or postmenopausal females * Past (\<6 year) or present use of nicotine products * Use of cannabis products * Use of any other medications that may affect study outcomes (e.g. anti-depressants) * Participants who have had a number of CT scans in the course of the year * Participants following a vegan diet
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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School of Health, Concordia University
Montreal, Quebec, H4B 1R6, Canada
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