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Can probiotics boost antibiotic success against gut bacteria overgrowth?

NCT ID NCT06223685

Disease control Sponsor: Pomeranian Medical University Szczecin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether taking probiotic supplements alongside the antibiotic rifaximin helps people with SIBO feel better. 129 adults with bloating or constipation took either probiotics or a placebo for 3 months. The goal was to see if the combination reduced symptoms and improved breath test results. This is a disease control study because it aims to manage symptoms, not cure the condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

129 people

The number who actually took part.

Started

Apr 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * positive hydrogen OR methane breath test * SIBO symptoms seen as: moderate or severe bloating for at least 50% of days in the past 3 months if hydrogen test (+) OR constipation (\< 3 bowel movements/week) in the past 3 months if methane test (+) Exclusion Criteria: * age \<18 * age \>70, * current proton pump inhibitor therapy, * antibiotic therapy in the past 3 months, * probiotic therapy in the past 2 weeks, * daily intake of \>30 g of ethanol for men * daily intake of \>20 g of ethanol for women, * hepatitis B or C virus infection, * other liver disease, * celiac disease, * severe chronic disease (m.e.g. chronic kidney disease, congestive heart failure, cancer, liver failure), * current symptoms of acute infection, * pregnancy, * vegan diet or following non-recommended diets such as ketogenic, * patients with very high physical activity (\> 5 x week of 100 min of strength training).

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome small intestinal bacterial overgrowth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irritable bowel syndrome SIBO Small intestinal bacterial overgrowth

Contacts and locations

Locations

  • Sonomed CENTRUM MEDYCZNE

    Szczecin, West Pomeranian Voivodeship, 71-032, Poland

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