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Good bacteria vs. bad cramps: probiotics tested for menstrual relief

NCT ID NCT07530081

Symptom relief Sponsor: Glac Biotech Co., Ltd Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking a daily probiotic supplement can reduce menstrual pain and premenstrual symptoms in women. 150 women with moderate-to-severe period pain will take either a high or low dose of probiotics or a placebo for four menstrual cycles. Researchers will track changes in pain, mood, and sleep quality using standard questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotic (Lactobacillus rhamnosus F-1)
What this could lead to
If it works, this could offer a natural, side-effect-free option for managing period pain and premenstrual symptoms.
What could go wrong
This is a small, early-stage trial with no phase designation. Probiotics may not outperform placebo, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

150 people

The number who actually took part.

Started

Mar 2024

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female aged between 20 and 65 years. * Regular menstrual cycles. * During the last three menstrual periods, self-reported dysmenorrhea with a pain score ≥ 3 on the Numeric Rating Scale (NRS). * Able to use effective contraception during the study period. * Willing to participate in the study and has signed the informed consent form. Exclusion Criteria: * Planning to become pregnant, currently pregnant, or in the postpartum stage with menstruation not yet resumed. * Postmenopausal women. * Irregular menstrual cycles (cycle length \< 21 days or \> 40 days). * Currently taking any psychiatric medications, oral contraceptives, menstrual regulation drugs, weight-loss drugs, or antibiotics. * Consumption of probiotic-related products within the past 1 month (including drops, tablets, capsules, powder, or yogurt and fermented milk products).

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Conditions

The condition(s) this trial relates to.

dysmenorrhea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dysmenorrhea

Contacts and locations

Locations

  • China Medical University Hospital

    Taichung, 404, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.