Could probiotics calm your bladder and your anxiety?
NCT ID NCT07635212
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether taking a daily probiotic powder can help adults with overactive bladder (OAB) and anxiety. About 218 people will take either probiotics or a placebo for 12 weeks, while everyone also learns bladder training. The main goals are to see if probiotics reduce how often they need to urinate and lower their anxiety levels.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Multi-strain probiotic powder (Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus)
- What this could lead to
- If it works, this could offer a simple, natural way to ease overactive bladder symptoms and anxiety when added to standard bladder training.
- What could go wrong
- This is an early-stage trial with no phase designation, so results are uncertain. The effect may be small or no better than placebo, and the study hasn't started recruiting yet.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 218 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Jul 2026
An estimate. Start dates often move.
- Expected to finish
-
Dec 2028
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 80 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged between 18 and 80 years old (inclusive). 2. Able to understand study-related instructions and independently complete the required questionnaires. 3. Able to provide written informed consent and willing to comply with all study requirements, including completing diaries/questionnaires and refraining from taking any other probiotic or prebiotic supplements during the 3-month study period. 4. Meet the diagnostic criteria for Overactive Bladder (OAB) as defined by the International Continence Society (ICS) (urgency as the core symptom, with or without urgency urinary incontinence, frequency, and nocturia); have an Overactive Bladder Symptom Score (OABSS) ≥ 6; and have a daytime voiding frequency of ≥ 8 times. 5. Have a preliminary diagnosis of "Generalized Anxiety Disorder" or "Anxiety state" assessed by a psychiatrist or trained investigator according to DSM-5 or ICD-10 criteria, or have a Generalized Anxiety Disorder-7 (GAD-7) scale score ≥ 5. 6. If previously using any over-the-counter medications or other products for anxiety relief (e.g., magnesium, melatonin, anticholinergic drugs) or receiving psychotherapy, these must have been discontinued for at least 4 weeks prior to randomization and must remain completely discontinued throughout the entire study period. Exclusion Criteria: 1. Presence of organic diseases of the urinary system (e.g., urinary tract obstruction, tumors, stones, acute infection, interstitial cystitis, stress urinary incontinence). 2. Neurogenic bladder caused by neurological diseases or a history of pelvic surgery. 3. Use of antibiotics, probiotics, or prebiotics within the past 1 month prior to screening. 4. Any adjustment to medications used for treating OAB or anxiety within the past 2 weeks prior to screening. 5. Pregnant or lactating women, or individuals with a known allergy to any components of the study preparation. 6. Suffering from other severe psychiatric/psychological disorders or severe systemic diseases (e.g., uncontrolled diabetes mellitus, severe obesity).
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Generalized anxiety disorder are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Qilu Hospital of Shandong University
Jinan, Shandong, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a cannabis tincture quiet an anxious mind?
- Can a computer game rewire anxious Kids' brains?
- Can a new Under-the-Tongue drug offer lasting relief for Treatment-Resistant anxiety?
- Can tailored brain stimulation quiet anxiety that drugs Can't?
- Can a smartphone app calm anxiety and protect the heart?
- A patch-like device zaps a leg nerve to calm an overactive bladder