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Could probiotics tame Chemo's worst symptoms?

NCT ID NCT06772090

Symptom relief Sponsor: Masonic Cancer Center, University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking probiotic supplements can help reduce common chemotherapy side effects like nausea, diarrhea, and loss of appetite in people with stage III colon cancer. Forty adults will be randomly assigned to receive either probiotics or a placebo during their chemo treatment. The main goal is to see if a larger, more definitive trial is even possible, so results will focus on how many people complete the study and how many side effects occur.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotic supplement (Lactobacillus and Bifidobacterium)
What this could lead to
If it works, this could point toward a simple way to reduce common chemo side effects like nausea and diarrhea for people with colon cancer.
What could go wrong
This is a very small, early feasibility trial with only 40 people. It is designed to test whether a larger study is possible, not to prove the probiotics work. Results may not apply to other cancers or treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥18 years old * Diagnosis of stage III colon cancer * Undergoing chemotherapeutic treatment within the MHFV or MVAHC medical systems. Exclusion Criteria: * Allergy or sensitivity to probiotic supplementation * Diagnosis/history of: Non-colon GI cancer or chronic GI-related disease or disorders such as gastric ulcer, irritable bowel syndrome, inflammatory bowel disease, or intestinal malabsorption syndrome Cognitive impairment, such as dementia, or developmental disorder that would affect ability to give consent or comply with study procedures * Current treatment of cancer other than non-melanoma skin cancer, including metastases and recurrences * Current participation in another interventional study of medication(s) * Major changes in eating habits within the past 3 months, such as stopping or starting a restricted diet * BMI ≥40 kg/m2 or ≤17 kg/m2 * Unexpected change in weight of ˃4.5 kg within the past 6 months

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Conditions

The condition(s) this trial relates to.

colon carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cytotoxicity Solid tumor, adult

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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