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Could a daily probiotic spray beat cavities in kids?

NCT ID NCT07241052

Prevention Sponsor: Anabio R&D Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a probiotic spray containing good bacteria can help prevent and treat cavities in children. 130 kids aged 7-10 will use the spray or a placebo twice daily for 3 months. Researchers will check if it reduces harmful mouth bacteria and slows cavity growth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bacillus subtilis and Bacillus clausii probiotic spray
What this could lead to
If it works, this could offer a simple, non-invasive way to help prevent cavities and improve oral health in children.
What could go wrong
This is an early-stage study with only 130 children, so results may not apply to everyone. The effect may be small, and cavities could still occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

7 to 10 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children (male or female) aged 7-10 years, currently enrolled in primary school (grades 2-4). * At least one decayed tooth (any stage) at the time of screening. * Commitment to comply with study requirements, including refraining from using any other probiotic products for the ear, nose, and throat that could affect study outcomes. * Written informed consent obtained from a parent or legal guardian. Exclusion Criteria: Participant-level exclusion: * Presence of severe chronic disease, allergy, or use of antibiotics within 1 month prior to study initiation. * Use of oral or throat probiotic sprays/lozenges within the past 30 days (excluding gastrointestinal probiotics). * Participation in another clinical study within the past 30 days. * Acute oral conditions (e.g., abscess, severe gingivitis) interfering with examination or intervention. * Currently receiving dental treatment at specialized dental/oral health facilities. * History of congenital immunodeficiency or infectious disease. * Psychiatric disorders or sleep disturbances. * Known sensitivity or allergy to components of the investigational product. Tooth-level exclusion: * Hard tissue lesions not caused by dental caries. * Supernumerary teeth or teeth not part of the functional dental arch. * Carious teeth with pain lasting \>10 seconds during examination. * Carious teeth with visible pulp hyperemia (high risk of pulp complications). * Teeth showing signs of pulp disease, pulp necrosis, or periapical pathology. * Teeth previously treated with endodontic therapy or permanently restored with crowns. * Primary teeth with mobility grade ≥2 (due to disease or natural exfoliation).

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Thanh My Primary School

    RECRUITING

    Hà Nội, Sơn Tây, 100000, Vietnam

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