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Could a probiotic boost weight loss after surgery?

NCT ID NCT05170867

Disease control Sponsor: Universidade Nova de Lisboa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a probiotic called Hafnia alvei HA4597 can help people lose more weight and control blood sugar better after gastric bypass surgery. 49 adults with obesity and type 2 diabetes took either the probiotic or a placebo twice a day for 90 days, starting one month after surgery. Researchers tracked weight loss and blood sugar levels over a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hafnia alvei HA4597 probiotic supplement
What this could lead to
If it works, this could point toward a simple probiotic to help people lose more weight and control blood sugar after weight-loss surgery.
What could go wrong
This is a small, early-stage trial with only 49 participants. The results may not apply to everyone, and the supplement may not provide any extra benefit beyond standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

49 people

The number who actually took part.

Started

Jan 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women between 18 and 65 years * BMI ≥35 kg/m2 and at least one severe obesity-related complications, or BMI ≥40 kg/m2 * Undergoing Roux-en-Y gastric bypass * Willing to take a probiotic/placebo supplement twice a day for 60 days * Willing and able to provide written informed Exclusion Criteria: * Intake of antibiotics and/or probiotics in the previous 12 weeks * Weight change \>5% in the previous 12 weeks * Diagnosis of gastrointestinal disease or other significant illness * Pregnancy or breastfeeding

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Type 2 diabetes

Contacts and locations

Locations

  • NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa

    Lisbon, 1169-056, Portugal

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