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Can a probiotic pill stop UTIs from coming back?

NCT ID NCT06192966

Disease control Sponsor: AB Biotics, SA Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a daily probiotic supplement containing Lactobacillus plantarum, cranberry, and vitamin C to see if it could prevent recurrent urinary tract infections (UTIs) in women. The trial planned to enroll 106 women with a history of frequent UTIs, but it was terminated early. Researchers aimed to measure how many women had another UTI and how long they stayed infection-free.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotic supplement with Lactobacillus plantarum, cranberry, and vitamin C
What this could lead to
If it worked, this supplement could help reduce the number of repeat urinary tract infections in women, offering a non-antibiotic option.
What could go wrong
The trial was terminated early, so results are limited. It was a small study, and supplements are not as strictly regulated as drugs, so effectiveness is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

106 people

The number who actually took part.

Started

Jan 2018

Finished

Mar 2022

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women over 18 years of age. * Women who have had at least one episode of UTI in the past 4 months * Women with a well-documented history of recurrent UTIs: ≥2 infections in the past 6 months or ≥3 in the past 12 months. * Women who have been treated with an antibiotic regimen for each episde of UTI * Recurrence due to reinfection, not relapse: multiple infections should be spaced by a minimum of 2 weeks or in case of a shorter time, with negative urine culture between them * Women who use contraception to prevent pregnancy and who do not plan a pregnancy during the study period Exclusion Criteria: * Pregnant or breastfeeding women * Underlying chronic disease: diabetes mellitus, kidney failure, cancer, spinal cord injury, polycystic ovary * Women wih catheters in the urethra * Women who consume probiotics or foods, beverages or supplements containing extracts or parts of the genus Vaccinum sp, including other forms of V. macrocarpon (blueberry), V. myrtillus (European blueberry), V. angustifolium (wild or low buch blueberry), V. corymbosum (tall bch blueberry) or V. vitis-ideae (mountain blueberry) during the 2 weels prior to recruitment. * High consumption of fruits rich in phenolic compounds, with special reference, to berries * Women allergic to red fruits

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Conditions

The condition(s) this trial relates to.

urinary tract infection urinary tract infections, recurrent, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Urinary tract infections

Contacts and locations

Locations

  • Fundació Puigvert

    Barcelona, Barcelona, 08025, Spain

  • Fundación Jiménez Díaz

    Madrid, Madrid, 28040, Spain

  • Hospital Universitario Virgen de Arrixaca

    Murcia, Murcia, 30120, Spain

  • Hospital Universitario de Caceres

    Cáceres, Cáceres, 1004, Spain

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