Probiotic pill may cut Kids' sore throat episodes
NCT ID NCT07235826
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This study tests whether a daily probiotic tablet called Bactoblis Evol can reduce how often children aged 3 to 11 get tonsillitis. Two hundred children with a history of at least three episodes in the past year will take either the probiotic or a placebo for three months, then switch. Researchers will track episodes, antibiotic use, and school absences.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Streptococcus salivarius Evol12 probiotic
- What this could lead to
- If it works, this could offer a simple, daily probiotic to help children have fewer and shorter tonsillitis episodes, reducing the need for antibiotics or surgery.
- What could go wrong
- This is a small, early-stage trial with only 200 children. The effect may be small or no better than placebo, and results may not apply to all children.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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216 people
The number who actually took part.
- Started
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Nov 2025
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
3 to 11 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male and female children aged 3 to 11 years. * History of ≥3 documented episodes of acute adenotonsillitis within the previous 12 months, each characterized by fever ≥38°C. * Signed and accepted informed consent from a parent or legal guardian. Exclusion Criteria: * Total obstruction of the nasal cavities. * Uncontrolled gastroesophageal reflux disease. * Unilateral tonsillar enlargement. * Previous tonsil reduction surgery. * Lack of parental or legal guardian consent to participate in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Università di Urbino Carlo Bo
Urbino, PU (Pesaro E Urbino), 61029, Italy
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