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Dental implant breakthrough? growth factor showdown could boost bone healing

NCT ID NCT05595772

Disease control Sponsor: Minia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two types of growth factor membranes (PRGF and CGF) placed around dental implants to see which helps bone heal better. Twenty patients with a damaged front tooth received an implant right after tooth removal, plus one of the membranes. The goal was to measure bone density and bone level around the implant. Results could help dentists choose the best option for implant success.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Growth factors (PRGF and CGF) applied as biological membranes
What this could lead to
If one membrane works better, it could improve bone healing and reduce implant failure in dental procedures.
What could go wrong
This is a small, early study with only 20 patients, so results may not apply to everyone. The treatments are not proven to be better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Feb 2022

Finished

Aug 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Selected patients of both sexes are 20-40 years old. 2. Patients are systemically healthy based on questionnaire dental modification of Cornell index. 3. Gingival health according to the new classification system (2017) 4. The recipient site of the implant is free from any pathological conditions. 5. Class II extraction socket according to Chang's classification system 6. Adequate interocclusal space to accommodate the available restorative components. 7. Adequate native/apical bone to achieve primary implant stability. Exclusion Criteria: 1. Pregnant female. 2. Para-functional habits such as bruxism and clenching Patients suffering from periodontitis. 3. Smokers.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental implant failure nos

Contacts and locations

Locations

  • Faculty of Dentistry Minia University

    Minya, 61519, Egypt

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