Jaw fracture patients may regain sensation with own blood product
NCT ID NCT07319650
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether applying platelet-rich fibrin (PRF) — a concentrate made from a patient's own blood — to the mental nerve during jaw fracture surgery can improve recovery of sensation in the chin and lower lip. 40 people with a broken jaw and numbness will be randomly assigned to receive either standard surgery plus PRF or standard surgery alone. The main outcome is the ability to feel two pinpricks at different distances on the skin, measured before surgery, right after, and at 6 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- platelet-rich fibrin (PRF)
- What this could lead to
- If it works, this could offer a simple, low-cost way to improve nerve healing after jaw fractures, reducing numbness in the chin and lip.
- What could go wrong
- This is a small, early-stage trial with only 40 people. The benefit may be small or not apply to everyone. PRF is made from the patient's own blood, so risks are low but not zero.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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15 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients having neurosensory disturbance following mandibular body fracture involving mental foramen and pre-operative TPD discrimination score '0' or '1' will be selected in this study ( as per operational definition). TPD discrimination will be recorded; Preoperatively Immediately post operatively After 6 months Age 15-40years, Both Gender ASA\_1 Exclusion Criteria: * Comminuted mandibular fractures Previously treated cases of fractures Patients with history of neurological disorders Comorbid patients
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Allama Iqbal Medical College/ Jinnah Hospital Lahore
Lahore, Punjab Province, 54550, Pakistan
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