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Can a drug in the breathing tube stop Post-Surgery sore throat?

NCT ID NCT07202624

Symptom relief Sponsor: Prince Sultan Military Medical City Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding dexmedetomidine or alkalinized lidocaine to the breathing tube cuff could prevent sore throat after long surgery where patients lie face down. Only 4 adults having spine surgery took part. Researchers checked for sore throat, hoarseness, and cough in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine and alkalinized lidocaine
What this could lead to
If it works, this could point toward a simple way to reduce sore throat after surgery, improving patient comfort.
What could go wrong
This is a very small, early-phase trial with only 4 participants, so results may not apply to larger groups. The drugs may not work better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

4 people

The number who actually took part.

Started

Feb 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 18 to 75 years * American Society of Anesthesiologists (ASA) physical status I and II patients * Either sex * Undergoing lumbar spine surgery in prone position under general anesthesia with endotracheal intubation. Exclusion Criteria: * Patients with a history of recent respiratory tract infection * Prior medication with analgesics or corticosteroids. * Patients who have preoperative sore throat, hoarseness and cough, have a nasogastric tube, * Patients with Mallampati class \> 2 and who required more than one attempt for tracheal intubation or patients had a duration of tracheal intubation of \< 60 min or \> 300 min and * Patients not willing to provide their voluntary written informed consent.

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Conditions

The condition(s) this trial relates to.

pharyngitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sore throat

Contacts and locations

Locations

  • Prince Sultan Military Medical City

    Riyadh, 12232, Saudi Arabia

More trials for these conditions

Other studies related to the condition(s) this trial covers.