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Simple infusion may keep blood pressure stable during emergency surgery

NCT ID NCT07529795

Prevention Sponsor: Bach Mai Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if giving a low-dose norepinephrine drip just before anesthesia can prevent low blood pressure during emergency surgery for a serious belly infection (peritonitis). About 60 adults with stable blood pressure after initial treatment will be randomly assigned to receive either the drug or a placebo. The main goal is to see how long blood pressure stays too low during the start of surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Secondary peritonitis requiring emergency surgery under general anesthesia with endotracheal intubation. * Planned induction with fentanyl, propofol, and rocuronium according to the study protocol. * Hemodynamically stabilized after initial resuscitation, with MAP at least 65 mmHg and no ongoing vasopressor infusion before induction. * ASA physical status I to III. * Written informed consent from the participant or a legally authorized representative. Exclusion Criteria: * Allergy or contraindication to norepinephrine, propofol, fentanyl, or rocuronium. * Severe cardiovascular disease likely to confound hemodynamic assessment, including decompensated heart failure, acute coronary syndrome, severe arrhythmia, severe valvular disease, or major cardiomyopathy. * Ongoing vasopressor therapy before induction. * Shock before surgery, including hypovolemic, septic, or cardiogenic shock. * Severe hypertension before induction (systolic blood pressure \>180 mmHg or mean arterial pressure \>110 mmHg). * Severe peripheral vascular disease or clinically significant limb ischemia. * Current monoamine oxidase inhibitor use. * Pregnancy or breastfeeding. * Contraindication to arterial catheter placement. * Refusal of consent.

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Conditions

The condition(s) this trial relates to.

peritonitis septic peritonitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-induction hypotension Secondary peritonitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital

    Hanoi, Vietnam

More trials for these conditions

Other studies related to the condition(s) this trial covers.