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Chronic pain before joint surgery linked to Post-Op depression in seniors, study finds

NCT ID NCT07403838

Knowledge-focused Sponsor: Chinese PLA General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether older adults with long-term pain before knee or hip replacement are more likely to feel depressed after surgery. Researchers analyzed data from 575 patients aged 65 and older. They found that chronic pain before surgery may predict depressive symptoms within the first week after the operation, which could help doctors better support recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

575 people

The number who actually took part.

Started

Apr 2022

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study is a secondary analysis based on a multicenter prospective database. We included 881 elderly patients who underwent elective joint replacement surgery at multiple medical centers between April 2020 and April 2022. The data were sourced from the Perioperative Database of Elderly Patients in China, which is a multicenter prospective study. The primary aim of this parent study was to identify perioperative risk factors in elderly patients undergoing non-cardiac surgery and to establish a targeted risk prevention and management system, utilizing data collected over a two-year period from 19 hospitals across the nation.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 65 years. 2. No cognitive impairment or history of mental illness. 3. Underwent elective joint replacement surgery. 4. Completed postoperative assessments, including questionnaires for depression, anxiety, and delirium. Exclusion Criteria: 1. Non-general anesthesia. 2. Patients admitted to the intensive care unit postoperatively. 3. Medical centers with fewer than 50 cases. -

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative depression

Contacts and locations

Locations

  • Department of Anesthesiology, First Medical Center of the People's Liberation Army General Hospital

    Beijing, Haidian, 100853, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.