Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Root canal relief: preemptive pain pills tested

NCT ID NCT07400471

Symptom relief Sponsor: Chattogram International Dental College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving pain medicine before a root canal can lower pain during and after the procedure. 280 adults with moderate to severe tooth pain will receive either a combination of pregabalin and acetaminophen, duloxetine and acetaminophen, or a placebo before treatment. Researchers will measure pain levels at several time points to see which approach works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pregabalin, Acetaminophen, Duloxetine
What this could lead to
If it works, this could lead to a simple way to make root canals less painful by taking medication beforehand.
What could go wrong
This is a very early, small trial. The drugs may not work better than placebo, and side effects like dizziness or drowsiness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 280 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient's aged 18 years more. 2. ASA physical status I-II. 3. Patient with the complain of pain originated from teeth and surrounding structure. 4. Preoperative pain severity is moderate to severe. 5. Patient can be able to make communication about their pain. 6. Patients give consent to attain this research. 7. Patients have others concomitant chronic pain. 8. Patients who will have non-surgical endodontic treatment. 9. Patients who will have non-surgical endodontic retreatment. 10. Patients who will have surgical endodontic treatment. Exclusion Criteria: 1. Patient would not like to attain in research. 2. Patients have any medical condition those are contra indication for study drug. 3. ASA physical status III, IV, V. 4. Patient already under treated any anti convulsent drug. 5. Patient participant in other clinical trials. 6. Lack of motivation or poor adharence to study protocols. 7. Patient with Pregnancy 8. Severe organ dysfunction 9. Patient have Hepatitis B, and other cross infection disease like (HIV) 10. Uncontrolled comorbidities that patient do not fit for endodontic treatment. 11. Severe cognitive impaired patients. 12. History of certain cancers or severe hematological issues.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Mechanical detection threshold are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical detection threshold Mechanical pain sensitivity Mechanical pain threshold Post endodontic pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Professor. Dr. Md. Abu Saeed Ibn Harun

    RECRUITING

    Chittagong, Chattogram, 4212, Bangladesh

More trials for these conditions

Other studies related to the condition(s) this trial covers.