Simple ultrasound scan may spot twin pregnancy dangers early
NCT ID NCT06935422
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at whether a special ultrasound measurement called the cerebroplacental ratio (CPR) can predict serious complications in monochorionic (identical) twin pregnancies. Researchers will measure CPR differences between twins at 16-20 weeks and track outcomes like twin-to-twin transfusion syndrome and growth problems. The goal is to find a way to identify high-risk pregnancies early for better care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could give doctors a simple way to identify high-risk twin pregnancies early, allowing closer monitoring and timely interventions.
- What could go wrong
- This is a small, early-stage observational study with only 55 participants. The ultrasound measurement may not reliably predict complications, and results may not apply to all pregnancies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 55 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2025
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Monochorionic diamniotic twin pregnancies with discordant cerebroplacental ratio at 16-20 weeks of gestation presenting to Ain Shams University Maternity Hospital for antenatal care.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Female participants only
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18 years or more and able to consent. * Monochorionic Diamniotic twin pregnancy. * Discordant inter-twin cerebroplacental ratio at 16-20 weeks of gestation. Exclusion Criteria: * Fetal structural malformations or chromosomal abnormalities in any of the twins as detected by anomaly scan antenatally or neonatal examination postnatally (chromosomal abnormalities and some congenital malformations can interfere with normal fetal growth). * Identified infectious etiologies detected during immediate postnatal examination or during pregnancy (fetal infections can cause FGR ,usually symmetric type particularly if they occur in early gestation). * Referral after development of Twin to twin transfusion syndrome, twin anemia polycythemia sequence or selective fetal growth restriction. * Single fetal demise at the time enrollment in the study. * Conjoint twins.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Ain shams maternity hospital
RECRUITINGCairo, Egypt
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