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Your DNA might predict radiation side effects

NCT ID NCT02489084

Knowledge-focused Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at whether a person's genetic makeup can help predict which head and neck cancer patients will experience side effects from radiation therapy, such as difficulty swallowing, dry mouth, and other complications. Researchers will collect blood samples from about 2000 patients to analyze genetic variations and see if they improve existing prediction models. The goal is to enable more personalized radiation treatment plans that minimize harm to healthy tissue.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood sampling for genetic analysis
What this could lead to
If genetic profiles improve prediction, doctors could tailor radiation plans to each patient, potentially reducing side effects like swallowing problems and dry mouth.
What could go wrong
The study is observational and exploratory, so it may not find reliable genetic links. Even if found, the models need validation before changing clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

2,000 people

The number who actually took part.

Start date

Sep 2013

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients ≥18 years still alive and treated since April 2007 for HNC at the department of Radiation Oncology of the UMCG, Groningen, the Netherlands

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histological proven head and neck cancer * Primary site in the oral cavity, oropharynx, hypopharynx, nasopharynx, paranasal sinuses, and/or salivary glands * Treatment with curative intent with primary or postoperative radiotherapy either or not combined with systemic treatment * Northern European ethnicity (ethnicity is a known confounder in SNP association studies) * Willing and able to comply with the study prescriptions * 18 years or older * No prior radiation (in the head and neck area) * Patients must have sufficient knowledge of the Dutch language to understand the meaning of the study as described in the patient information * Have given written informed consent before patient registration Exclusion Criteria: * Prior radiotherapy

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck cancer

Contacts and locations

Locations

  • University Medical Center Groningen

    Groningen, Provincie Groningen, 9700RB, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.