Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Zapping nerves before knee surgery may cut pain — trial puts it to the test

NCT ID NCT07727551

Symptom relief Sponsor: Anesthesiology department Iris South Hospitals Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether a nerve-blocking procedure called genicular nerve radiofrequency ablation, done two to six weeks before total knee replacement, can reduce postoperative pain and improve function. The study includes adults aged 18 to 60 who are scheduled for knee replacement and have certain risk factors like obesity, diabetes, or chronic pain. Participants are randomly assigned to receive the nerve block or not, and their pain and mobility are tracked after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radiofrequency ablation of the genicular nerve
What this could lead to
If it works, this could offer a way to reduce pain and speed up recovery after knee replacement surgery.
What could go wrong
This is a small early-stage trial, so results may not apply to everyone. The procedure carries risks like nerve damage or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 60 * Elective total knee arthroplasty * 2 to 6 weeks before the procedure AND either of: * BMI \> 35 * Diabetes under insulin * Anxiety disorder * Treated depressive disorder * Widespread pain disorder or central sensitisation disorder * Chronic pain at a different site * Catastrophising * Sleep disorder * preoperative EVA 7 or more * OKS 25 or less * WOMAC 50 or more * Previous total knee arthroplasty (contralateral) * Knee CRPS Exclusion Criteria: * Previous prosthetic surgery on the same knee (i.e. redo surgery, open reduction internal fixation, knee hemiarthroplasty) * Major psychiatric disorder (i.e. major depression, schizophrenia) * Patient refusal * Inability to communicate with the patient and obtain informed consent

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for 18 years and older are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

18 years and older Total knee arthroplasty secondary to osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Iris South Hospitals

    RECRUITING

    Brussels, 1050, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.