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Pre-op IV fluids may keep blood pressure stable during surgery

NCT ID NCT05079269

Knowledge-focused Sponsor: Medical University of Graz Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether giving IV fluids before surgery can prevent low blood pressure after anesthesia is started. Researchers will monitor 550 adults at risk for blood pressure drops during major non-cardiac surgery. The goal is to see if this simple step reduces the need for emergency medications and improves patient outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Crystalloid solutions (IV fluids)
What this could lead to
If it works, this could point toward a simple way to reduce blood pressure drops during surgery, potentially improving recovery.
What could go wrong
This is an early-stage observational study, not a treatment trial. Results may not change standard care, and individual responses to fluids vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

550 people

The number who actually took part.

Started

Nov 2021

Expected to finish

Nov 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Scheduled for major non-cardiac surgery 2. Having general anaesthesia 3. Are designated ASA physical status ≥2 (ranging from mild systemic disease through severe systemic disease that is a constant threat to life) 4. Subject to at least one of the following risk factors: 1. Age ≥ 65 years 2. History of peripheral arterial surgery 3. History of coronary artery disease 4. History of stroke or transient ischemic attack 5. Serum creatinine \>175 µmol/L (\>2.0 mg/dl) 6. Diabetes requiring medication 7. Current smoking or 15 pack-year history of smoking tobacco 8. Preoperative high-sensitivity troponin T \>14 ng/L or troponin I equivalent, defined as ≥15 ng/L (Abbott assay),75 19 ng/L (Siemens assay, \[Borges, unpublished\]), or 25% of the 99% percentile for other assays; 9. B-type natriuretic protein (BNP) ≥ 80 ng/L or N-terminal B-type natriuretic protein (NT-ProBNP) ≥ 200 ng/L.76,77 10. History of atrial fibrillation 11. Chronically taking at least one anti-hypertensive medication Exclusion Criteria: 1. Are scheduled for carotid artery surgery 2. Are scheduled for intracranial surgery 3. Are scheduled for pheochromocytoma surgery 4. Require preoperative intravenous vasoactive medications 5. Active decompensated congestive heart failure (documented EF \< 30%) 6. Chronic Kidney Disease (eGFR\< 30 mL/min) 7. History of organ transplantation 8. Rectal surgical procedures 9. Patients receiving preoperative bowel preparation 10. Severe pulmonary edema

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Hypotension drug-induced

Contacts and locations

Locations

  • Medical University Graz

    Graz, Styria, 8036, Austria

  • Medical University Vienna

    Vienna, State of Vienna, Austria

More trials for these conditions

Other studies related to the condition(s) this trial covers.