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Could a plasma injection help athletes heal muscles faster?

NCT ID NCT07566039

Disease control Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a single injection of platelet-poor plasma (PPP) into an acute muscle injury helps athletes heal better than standard care. About 90 athletes aged 18-45 with leg muscle strains will receive the injection plus physical therapy. Researchers will use MRI scans to measure scar tissue and muscle regrowth over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-poor plasma (PPP) injection
What this could lead to
If it works, this could offer a better way to heal muscle injuries in athletes, reducing scar tissue and improving recovery.
What could go wrong
This is a small, early-stage study with only 90 participants, and it hasn't started yet. The treatment may not prove better than standard care, and results may not apply to all injuries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 45 years * Diagnosis of a muscle strain in the lower extremities, including but not limited to hamstring, quadriceps, and gastrocnemius * Injury occurred within 10 days of the initial clinical evaluation * Injury occurred while engaging in athletic or sporting activities * Participants must be willing to undergo prescribed physical therapy * Participants have agreed to standard-of-care management for their injury, which may include ultrasound-guided aspiration with or without a platelet-poor plasma injection Exclusion Criteria: * Previous injection at the injury site. * Pregnant or breastfeeding women, or women who may become pregnant during the study duration * Injuries resulting from puncture or crush trauma * Injuries occurring more than 10 days prior to the injection date * Injuries not caused by athletic or sporting activity * Previous muscle injury in the same muscle group within 6 months

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lower extremity injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Emory University

    Atlanta, Georgia, 30322, United States

  • University of Colorado | Steadman Hawkins Clinic Denver

    Englewood, Colorado, 80112, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

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