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Motorized brace aims to unload painful knees without surgery

NCT ID NCT07673328

Symptom relief Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This study tests a modular, powered leg brace (exoskeleton) designed to assist knee movement and reduce pain in people with knee osteoarthritis. The brace provides a small amount of torque to help the joint, potentially lowering muscle effort and painful loads on the knee. Researchers will measure changes in pain, muscle activity, and walking speed in up to 65 participants, including both healthy adults and those with knee OA.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Modular powered orthosis (exoskeleton)
What this could lead to
If successful, this device could offer a non-drug, non-surgical way to reduce knee pain and improve mobility for people with knee osteoarthritis.
What could go wrong
This is an early feasibility study with only 65 participants, so results may not apply to everyone. The device may not reduce pain enough to be practical.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 65 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Mar 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion criteria for able-bodied, young participants will be: * Aged between 18 to 65 years * Weigh less than 300 lbs (due to challenges in bracing heavier participants) * BMI \< 40 (due to challenges in bracing heavier participants) Inclusion criteria for knee osteoarthritis participants will be: * Aged between 30 to 85 years * Medical diagnosis of patellofemoral and tibiofemoral osteoarthritis * Patient reported pain ≥ 4 out of 10 during activities of daily life (to avoid floor effects) * Weigh less than 300 lbs (due to challenges in bracing heavier participants) * BMI \< 40 (due to challenges in bracing heavier participants) * Ability to walk 6 minutes without assistance from a person (may use walking aid) * Ability to ascend/descend ramps and stairs with or without the use of handrails Exclusion Criteria: Exclusion criteria for able-bodied, young adult participants will be: * Pregnant (self-report) * Any significant neuromuscular or musculoskeletal disorder that would interfere with the study * Unable to walk for 20 minutes * History of any cardiovascular, vestibular, or visual diseases and/or impairments that may interfere with the study * Cognitive deficits that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \<22. * Adults with a known allergy to medical grade tape Exclusion criteria for knee osteoarthritis participants will be: * Pregnant (self-report) * Any recent lower-extremity fracture (within 6 months) * Significant limitation on knee joint range of motion * Significant neurological (e.g., stroke) or cardiovascular disorder that may affect the ability to walk * Advised by a physician not to walk or exercise * Uncontrolled hypertension or diabetes * Use of opioids * Cognitive deficits or visual impairment that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \<22. * Adults with a known allergy to medical grade tape

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lower-limb orthoses Osteoarthritic knee pain Osteoarthritis (OA) of the knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Rehab Lab

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

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