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New drug could soothe uncontrollable itch in rare skin condition

NCT ID NCT06516952

Symptom relief Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests an oral drug called povorcitinib in 349 adults with prurigo nodularis, a condition causing intense itching and hard skin bumps. Participants receive either the drug or a placebo for 24 weeks. The goal is to see if the drug reduces itch and clears skin lesions better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Povorcitinib (an oral tablet that targets inflammation)
What this could lead to
If it works, this could provide a new treatment option to ease severe itching and clear skin bumps in people with prurigo nodularis.
What could go wrong
This is a phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects are possible. It is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

349 people

The number who actually took part.

Started

Oct 2024

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female participants 18 to 75 years of age. * Clinical diagnosis of PN for at least 3 months prior to Screening visit. * Pruritus, defined as an average Itch NRS score ≥ 7 during the 7 days prior to Day 1/Baseline. * Total of ≥ 20 pruriginous lesions on ≥ 2 different body regions (both legs, and/or both arms, and/or trunk) at Screening and Day 1/Baseline. * Documented history of treatment failure, demonstrated intolerance, or contraindication to a previous PN treatment. * Willingness to avoid pregnancy or fathering children. Exclusion Criteria: * Chronic pruritus due to a condition other than PN or neuropathic and psychogenic pruritus. * Diagnosis of PN secondary to medications. * Active AD lesions (signs and symptoms other than dry skin) within 3 months prior to Screening visit. * Women who are pregnant (or are considering pregnancy) or breastfeeding. * Medical history including thrombocytopenia, coagulopathy or platelet dysfunction; venous and arterial thrombosis, deep vein thrombosis, pulmonary embolism, stroke, moderate to severe heart failure, cerebrovascular accident, myocardial infarction, or other significant cardiovascular diseases; Q-wave interval abnormalities; disseminated herpes zoster or dermatomal herpes zoster; disseminated herpes simplex; chronic/recurrent infections; malignancies. * Evidence of infection with TB, HBV, HCV or HIV. * History of failure to any topical or systemic JAK or TYK2 inhibitor as treatment of PN or any inflammatory disease. * Laboratory values outside of the protocol-defined ranges. Other protocol-defined Inclusion/Exclusion Criteria apply.

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Conditions

The condition(s) this trial relates to.

prurigo nodularis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prurigo nodularis

Contacts and locations

Locations

  • Aachen University Hospital

    Aachen, 52074, Germany

  • Alpha Research-Lucere Dermatology and Laser Clinic

    Edmonton, Alberta, T6X 0N9, Canada

  • Amsterdam Universitair Medisch Centrum, Locatie Amsterdam Medisch Centrum

    Amsterdam, 1105 AZ, Netherlands

  • Aou Universita Della Campania Luigi Vanvitelli, Azienda Ospedaliero Universitaria Federico Ii Di Nap

    Naples, 80131, Italy

  • Azienda Ospedaliera Di Perugia

    Perugia, 06129, Italy

  • Azienda Ospedaliero Universitaria Pisana - Ospedale S. Chiara

    Pisa, 56126, Italy

  • Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele Ospedale Gaspare Rodolico Di Catania

    Catania, 95123, Italy

  • Azienda Sanitaria Locale 1 (Asl 1) - Ospedale Regionale San Salvatore

    L’Aquila, 67100, Italy

  • Banner - University Medicine Multispecialty Services Clinic

    Tucson, Arizona, 85718, United States

  • Burke Pharmaceutical Research

    Hot Springs, Arkansas, 71913, United States

  • Cabinet Medical- Chemin de Paradis

    Martigues, 13500, France

  • Cahaba Dermatology

    Birmingham, Alabama, 35244, United States

  • Catholic University of the Sacred Heart

    Rome, 00168, Italy

  • Cedic - Centro de Investigacion Clinica

    Buenos Aires, C1060ABN, Argentina

  • Center For Clinical Studies

    Webster, Texas, 77598, United States

  • Center For Medical Dermatology and Immunology Research

    Chicago, Illinois, 60657, United States

  • Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hopital Hotel Dieu

    Nantes, 44093, France

  • Centre de Recherche Dermatologique de Quebec

    Québec, Quebec, G1V4X7, Canada

  • Centre de Recherche Saint-Louis

    Québec, Quebec, G1W 4R4, Canada

  • Centricity Research Columbus

    Columbus, Ohio, 43213, United States

  • Centricity Research London Victoria Multispecialty

    London, Ontario, N6A 2C2, Canada

  • Centro de Investigaciones Medicas Mar Del Plata

    Mar del Plata, B7600FYK, Argentina

  • Centrum Badan Klinicznych, Jagiellonskie Centrum Innowacji Sp.Z.O.O.

    Krakow, 30-348, Poland

  • Centrum Medyczne Evimed

    Warsaw, 02-625, Poland

  • Charite Universitatsmedizin Berlin

    Berlin, 12203, Germany

  • Chicago Cosmetic Surgery and Dermatology

    Chicago, Illinois, 60654, United States

  • Chu Paris-Gh St-Louis Lariboisiere F.Widal Hopital Saint-Louis

    Paris, 75010, France

  • Clinical Research Centre - Cast

    Chieti, 66013, Italy

  • Clinical Research Group Sp. Z.O.O

    Warsaw, 01-142, Poland

  • Conexa Investigacion Clinica S.A.

    Buenos Aires, 01012, Argentina

  • Dermaceum Centrum Badan Klinicznych

    Wroclaw, 53-613, Poland

  • Dermatology Research Associates

    Los Angeles, California, 90045, United States

  • Dermatology Research Institute

    Calgary, Alberta, T2J 7E1, Canada

  • Dermatology Specialists Research Indiana

    Clarksville, Indiana, 47129, United States

  • Dermatology Treatment and Research Center

    Dallas, Texas, 75230, United States

  • Dermeffects

    London, Ontario, N6H 5L5, Canada

  • Diagnostic-Consultative Center Aleksandrovska Eood

    Sofia, 01431, Bulgaria

  • Diagnostic-Consultative Center Ascendent Eood

    Sofia, 01202, Bulgaria

  • Diagnostic-Consultative Centre Pulmed Eood

    Plovdiv, 04002, Bulgaria

  • Diamond Clinic Sp. Z O.O.

    Krakow, 31-559, Poland

  • Driven Research Llc

    Coral Gables, Florida, 33134, United States

  • Dsc Clinic Buochs

    Buochs, 06374, Switzerland

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455, Germany

  • Frontier Dermatology

    Mill Creek, Washington, 98012, United States

  • Ghrmsa Hopital Emile Muller

    Mulhouse, 68100, France

  • Gyncentrum Sp. Z O.O., Nzoz Holsamed- Oddzial Libero

    Katowice, 40-600, Poland

  • Hamzavi Dermatology

    Fort Gratiot, Michigan, 48059, United States

  • Hautzentrum Friedrichshain Studien

    Berlin, 10247, Germany

  • Hopital Larrey

    Toulouse, 31400, France

  • Hopital Prive D Antony

    Antony, 92160, France

  • Hopitaux Drome Nord - Site de Romans Sur Isere

    Romans-sur-Isère, 26102, France

  • Hospital Morvan

    Brest, 29200, France

  • Illinois Dermatology Institute the Chicago Loop

    Chicago, Illinois, 60602, United States

  • Inselspital Bern

    Bern, 03010, Switzerland

  • Instituto Especialidades de La Salud Rosario - Clinica Del Torax

    Rosario, S2000, Argentina

  • Instituto de Investigaciones En Alergia Y Enfermedades Respiratorias (Inaer)

    Buenos Aires, C1425BEN, Argentina

  • Instituto de Neumonologia Y Dermatologia

    Buenos Aires, C1425BEA, Argentina

  • International Clinical Research Tennessee Llc

    Murfreesboro, Tennessee, 37130, United States

  • Investigaciones Reumatologicas Tucuman S.R.L.

    San Miguel de Tucumán, T4000AXL, Argentina

  • Irccs Istituto Clinico Humanitas

    Rozzano, 20089, Italy

  • Jeonbuk National University Hospital

    Jeonju, 54907, South Korea

  • Klinika Ambroziak Sp. Z O.O.

    Warsaw, 02-953, Poland

  • Klinikum Dortmund Ggmbh

    Dortmund, 44137, Germany

  • Konkuk University Medical Center

    Seoul, 05030, South Korea

  • Korea University Ansan Hospital

    Ansan-si, 15355, South Korea

  • Laser Clinic

    Szczecin, 70-332, Poland

  • Maxima Medisch Centrum

    Veldhoven, 5504 DB, Netherlands

  • Mazowieckie Centrum Badan Klinicznych

    Pruszków, 05-800, Poland

  • Medical Center Medconsult Pleven

    Lovech, 05500, Bulgaria

  • Medical Center Medconsult Pleven Ood

    Pleven, 05800, Bulgaria

  • Medical Center Prolet Eood

    Rousse, 07000, Bulgaria

  • Medical Center Unimed Eood

    Sevlievo, 05400, Bulgaria

  • Medical University Graz University Clinic For Dermatology and Venerology

    Graz, 08036, Austria

  • Medisearch Clinical Trials

    Saint Joseph, Missouri, 64506, United States

  • Montefiore Medical Center

    East Syracuse, New York, 13057, United States

  • Niepubliczny Zaklad Opieki Zdrowotnej Med-Laser

    Lublin, 20-406, Poland

  • Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczny Osrodek Dermatologiczny Dermal

    Bialystok, 15-453, Poland

  • North York Research Inc.

    Toronto, Ontario, M2N 3A6, Canada

  • Northridge

    Northridge, California, 91325, United States

  • Northshore University Healthsystem

    Skokie, Illinois, 60077, United States

  • Nzoz Gyncentrum - Oddzial Warszawa

    Warsaw, 00-124, Poland

  • Oakland Hills Dermatology

    Auburn Hills, Michigan, 48326, United States

  • Park Dermatology

    Sherwood Park, Alberta, T8H 0P1, Canada

  • Penta Hospitals Przychodnie, Wroclaw Wejherowska

    Wroclaw, 54-239, Poland

  • Premier Dermatology Clinical Trials Institute At Northwest Arkansas

    Fayetteville, Arkansas, 72703, United States

  • Pro Familia Altera Sp. Z O.O.

    Katowice, 40-648, Poland

  • Pusan National University Hospital (Pnuh)

    Busan, 49241, South Korea

  • Pusan National University Yangsan Hospital

    Busan, 50612, South Korea

  • Rao Dermatology

    Edmonton, Alberta, T6G 1C3, Canada

  • Rendon Center the Dermatology and Aesthetic Center

    Boca Raton, Florida, 33486, United States

  • Research Institute of the Southeast, Llc

    West Palm Beach, Florida, 33401, United States

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Sima Recherche

    Verdun, Quebec, H4G 3E7, Canada

  • Simcoderm Medical and Surgical Dermatology Centre

    Barrie, Ontario, L4M 7G1, Canada

  • Skin Center Dermatology Group

    New York, New York, 10956, United States

  • Skin Health

    Cobourg, Ontario, K9A 0Z4, Canada

  • Skin Physicians

    Edmonton, Alberta, T6W 4V4, Canada

  • Skinsense Medical Research

    Saskatoon, Saskatchewan, S7K 2C1, Canada

  • Somerset Skin Centre

    Troy, Michigan, 48084, United States

  • Soon Chun Hyang University Bucheon Hospital

    Bucheon-si, 14584, South Korea

  • Stony Brook Dermatology Associates

    Stony Brook, New York, 11790, United States

  • Sweetwater Dermatology

    Sugar Land, Texas, 77479, United States

  • The Catholic University of Korea, Incheon St. Mary'S Hospital

    Incheon, 21431, South Korea

  • The University of New Mexico Unm Health Sciences Center Hsc

    Albuquerque, New Mexico, 87131, United States

  • Toronto Research Centre

    Toronto, Ontario, M3H 5Y8, Canada

  • Universitaets-Hautklinik Eberhard-Karls-Universitaet Tuebingen

    Tübingen, 72076, Germany

  • Universitaetsklinik Und Poliklinik Fuer Dermatologie Und Venerologie

    Halle, 06120, Germany

  • Universitaetsklinikum Giessen Und Marburg Gmbh

    Marburg, 35043, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitaetsklinikum Leipzig

    Leipzig, 04103, Germany

  • Universitaetsklinikum Schleswig-Holstein (Uksh) - Campus Luebeck

    Lübeck, 23538, Germany

  • Universitaetsmedizin Der Johannes - Gutenberg Universitaet Mainz

    Mainz, 55131, Germany

  • Universitatsklinik Heidelberg

    Heidelberg, 69115, Germany

  • Universitatsspital Zurich

    Zurich, 08091, Switzerland

  • University of Miami Miller School of Medicine

    Miami, Florida, 33136, United States

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-214, Poland

  • Uoc Dermatologia Ospedale Maggiore Policlinico, Fondazione Irccs Ca' Granda

    Milan, 20122, Italy

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Wiener Krankenanstaltenverbund (Kav) - Krankenhaus Hietzing Mit Neurologischem Zentrum Rosenhuegel

    Vienna, 01130, Austria

  • Wright State Physicians Health Center

    Dayton, Ohio, 45324, United States

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