Can a CBD cream soothe Eczema's relentless itch?
NCT ID NCT06994520
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether a 5% cannabidiol (CBD) cream can reduce itching and skin severity in adults with chronic eczema conditions like atopic dermatitis and nummular eczema. About 60 participants will apply the CBD cream or a standard steroid cream for 4 weeks. The study measures changes in itch intensity and skin signs like redness and scaling, aiming to see if CBD offers a safer long-term option.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a 5% cannabidiol (CBD) cream
- What this could lead to
- If effective, this could offer a new, non-steroid option for managing chronic eczema itch and skin inflammation.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. CBD creams can cause skin irritation, and the effect may be no better than standard treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. All participants must be aged 25 years or older. 2. Patients must be diagnosed with eczema, including atopic dermatitis, nummular eczema, lichen simplex chronicus, or prurigo nodularis, with pruritus persisting for more than 6 weeks. 3. Patients must be willing to refrain from using other topical products throughout the 4-week study period. 4. Patients must provide written informed consent to participate in the study. Exclusion Criteria: 1. Patients who have taken oral steroids, immunosuppressive drugs, or received phototherapy within the past 3 months. 2. Patients with chronic kidney disease, liver cirrhosis, cancer, or thyroid disease. 3. Pregnant or breastfeeding women, or women planning to become pregnant. 4. Patients who develop erythematous itchy rash in response to an open patch test using cannabis extract products. 5. Patients with a known allergy to cannabis-derived products, which may result from other ingredients and/or solvents used in the extraction process. 6. Patients with severe or unstable cardio-pulmonary diseases (e.g., angina, peripheral vascular disease, cerebrovascular disease, or arrhythmia), or those at risk of cardiovascular disease. 7. Patients with a history of psychosis, current active mood disorder, or anxiety disorder. 8. Patients who are addicted to substances, including nicotine, or are heavy alcohol users. 9. Patients using other medications, particularly opioids or sedatives such as benzodiazepines. 10. Patients taking medications known to potentially interact with cannabis extracts, such as warfarin, fluoroquinolones, or dihydropyridine calcium channel blockers.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Khon Kaen University
Khon Kaen, Changwat Khon Kaen, 40002, Thailand
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a daily liquid medicine calm severe eczema in toddlers and preschoolers?
- Scientists probe whether lebrikizumab rewires diseased skin at the molecular level
- Can a Lab-Made antibody calm severe eczema?
- Is your nose fueling infected eczema and scabies sores?
- Can an eczema drug reshape the Skin's microbial community?