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New cocktail aims to tame Slow-Growing blood cancers
NCT ID NCT07609446
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This Phase II trial will test a combination of pomalidomide, an anti-CD20 antibody, and prednisone as a first treatment for people with indolent (slow-growing) B-cell lymphomas. About 30 adults who have not had prior therapy will receive six cycles of the combo, followed by two years of maintenance. The main goal is to see how many patients respond, while also tracking side effects and how long the benefit lasts.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Pomalidomide, anti-CD20 antibody (a targeted immune therapy), and prednisone (a steroid)
- What this could lead to
- If successful, this could offer a new first-line treatment option for indolent B-cell lymphoma that may improve response rates and delay disease progression.
- What could go wrong
- This is a small, early-phase (Phase II) trial with only 30 participants, so results may not apply broadly. The combination may cause side effects like low blood counts or infections, and it is not a cure—patients will need ongoing maintenance therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
patients with indolent B-cell lymphoma
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥ 18 years, regardless of sex; 2. Confirmed diagnosis of follicular lymphoma (FL), or histopathologically confirmed CD20-positive marginal zone lymphoma (MZL), including extranodal marginal zone lymphoma (MALT), splenic marginal zone lymphoma (SMZL), and nodal marginal zone lymphoma (NMZL),or confirmed diagnosis of indolent mantle cell lymphoma (MCL); 3. Patients with a confirmed diagnosis of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL); 4. Confirmed diagnosis of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia; 5. Presence of indications for treatment of indolent B-cell lymphoma; 6. No prior systemic antitumor therapy for lymphoma; 7. ECOG-PS score 0-2; 8. Essentially normal bone marrow hematopoietic function, with routine blood tests as follows: white blood cell count \>3000/uL, absolute neutrophil count ≥1.5 × 10\^9/L (use of granulocyte colony-stimulating factor is allowed), platelet count ≥75 × 10\^9/L (transfusion to reach this minimum platelet count is allowed), and hemoglobin ≥9.0 g/dL (prior red blood cell transfusion or use of recombinant human erythropoietin is allowed). If peripheral blood abnormalities are caused by lymphoma involvement of the bone marrow or spleen, neutrophils≥1.0 × 10\^9/L and platelets≥50 × 10\^9/L are acceptable (the investigator may determine at his/her discretion whether enrollment is appropriate); 9. Normal function of major organs: 1. Hepatic function: serum bilirubin ≤2.0 × ULN; serum ALT and AST ≤2.5 × ULN; 2. Renal function: creatinine clearance \>30 mL/min; 10. Expected survival≥3 months as judged by the investigator; Voluntary written informed consent signed before trial screening; Exclusion Criteria: 1. Current or prior other malignancy, unless curative treatment has been performed and there has been no evidence of recurrence or metastasis within the past 5 years; 2. Lymphoma involvement of the central nervous system or transformation to a higher-grade lymphoma; 3. Hepatic or renal dysfunction unrelated to lymphoma: alanine aminotransferase (ALT) \>3 times the upper limit of normal, aspartate aminotransferase (AST) \>3 times the upper limit of normal, total bilirubin (TBIL) \>2 times the upper limit of normal, or serum creatinine \>1.5 times the upper limit of normal; 4. Other serious medical conditions that would affect this study (e.g., uncontrolled diabetes, gastric ulcer, or other serious cardiopulmonary diseases). The investigator has the authority to make this determination; 5. Severe or uncontrolled infection; 6. Clinically manifest central nervous system dysfunction; 7. Major surgery within the past 30 days (excluding lymph node biopsy); 8. Pregnant or lactating women, or women of childbearing potential who have not used contraceptive measures; 9. Allergy to the study drug; Patients considered unsuitable for enrollment by the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New drug joins standard chemotherapy in fight against B-Cell lymphoma
- New antibody tested against aggressive blood cancer
- Which lymphoma drug combo works best? a new study aims to find out
- Can engineered immune cells beat tough B-Cell cancers?
- Can a new drug delay the need for lymphoma treatment?