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Heart surgery study aims to unravel platelet mysteries

NCT ID NCT07630987

Knowledge-focused Sponsor: Université Catholique de Louvain Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery inflammation and bleeding complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help doctors better predict and manage bleeding and inflammation after heart surgery.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to direct changes in patient care, and results might not apply to all heart surgery patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥ 18 years old) suffering from coronary disease and/or severe valvular dysfunction (mitral or aortic) undergoing elective coronary angiography or cardiac surgery with cardiopulmonary bypass. Exclusion Criteria: * Uninterrupted preoperative dual antiplatelet therapy * Active chronic inflammatory disease * Recent chemotherapy or immunotherapy (\< 3 months) * Active solid malignancy * History of hematologic malignancy * Hemophilia or other coagulopathy * History of thrombocytopenia (\< 100,000 platelets/mm³) * Recent administration of thrombopoietin receptor agonist or immunoglobulins * History of thrombopathy, thrombocytosis, or myeloproliferative syndrome * History of heparin-induced thrombocytopenia (HIT) * Cirrhosis or hepatic fibrosis (with or without hypersplenism) * History of splenectomy, regardless of initial indication * History of systemic autoimmune disease (e.g., systemic lupus erythematosus, scleroderma, antiphospholipid syndrome, systemic vasculitis) * Recent major surgery (\< 3 months) * Severe renal insufficiency (eGFR ≤ 30 mL/min/m²) with or without dialysis * Recent or chronic corticosteroid therapy * Recent acute coronary syndrome, STEMI type (\< 3 months) * Urgent surgery or procedure * Preoperative hemodynamic instability

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Conditions

The condition(s) this trial relates to.

aortic valve disorder coronary artery disorder mitral valve disorder Postoperative Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery Cardiopulmonary bypass Platelet activation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cliniques universitaires Saint-Luc

    Brussels, 1200, Belgium

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