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Fatty meal test reveals hidden clues about blood vessel health

NCT ID NCT05107869

Knowledge-focused Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study looks at how eating a high-fat meal changes levels of certain fats in the blood called ceramides, and whether those changes affect blood vessel function. Healthy adults aged 18 to 40 will eat either a meal rich in long-chain fatty acids (which raise ceramides) or medium-chain fatty acids (control). Researchers will measure blood flow and use a special microscope to check tiny blood vessels in the skin.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High saturated fat meal
What this could lead to
If this trial shows that ceramides impair blood vessel function, it could point toward new ways to prevent or treat peripheral vascular disease.
What could go wrong
This is a small, early-stage study in healthy adults, so results may not apply to people with existing disease. The effect of a single meal may not reflect long-term risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23 people

The number who actually took part.

Started

May 2023

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Health adults aged 18-40 years 2. English-speaking only 3. Not pregnant Exclusion Criteria: 1. Healthy individuals under 18 years or over 40 years of age 2. Non-English speaking 3. Pregnant individuals 4. Heart rate \<60 or \>100 5. Systolic blood pressure \<100 or \>160 6. Subjects with visible open sores or wounds in mouth 7. Lactose intolerant or allergy to dairy products 8. Diabetes Mellitus 9. Coronary Artery Disease 10. High blood pressure 11. High cholesterol 12. Heart failure 13. Current tobacco use 14. Chemotherapy within the last 6 months

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Conditions

The condition(s) this trial relates to.

hyperlipidemia Lipid Metabolism Disorders peripheral vascular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endothelial dysfunction Lipid disorder Peripheral vascular disease

Contacts and locations

Locations

  • Froedtert Hospital

    Wauwatosa, Wisconsin, 53226, United States

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