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One pill, many questions: could emergency contraception briefly alter blood vessel health?

NCT ID NCT07759635

Knowledge-focused Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial investigates whether a single dose of the emergency contraceptive Plan B (levonorgestrel) affects markers of blood clotting and blood vessel function in young, healthy, premenopausal women. Participants will have their blood and artery function measured before and at several time points after taking either Plan B or a placebo. The goal is to understand if this common pill has any short-term cardiovascular effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A single 1.5 mg dose of levonorgestrel (Plan B), an emergency contraceptive pill
What this could lead to
If it works, this could reveal whether a single emergency contraceptive dose has any short-term effects on blood clotting or artery health, informing safer use.
What could go wrong
This is a small, early study in healthy young women, so results may not apply to other groups. It only looks at short-term markers, not actual clot events, and the effects may be minimal or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Provide written informed consent. 2. Pre-menopausal female. 3. 18 - 35 years of age. 4. Naturally cycling (i.e., not using any form of hormonal contraception for ≥ 3 months). 5. Eumenorrheic (i.e., experiencing a predictable menstrual cycle lasting 21-45 days). 6. In the surrounding Hamilton area, or able to visit McMaster for study visits. 7. Not pregnant. Exclusion Criteria: 1. Known hypersensitivity to the active substance levonorgestrel or to any ingredient in this formulation (i.e., levonorgestrel colloidal silicon dioxide, potato starch, magnesium stearate, talc, cornstarch, lactose monohydrate, or any ingredient/excipient in the placebo capsule. 2. Known or suspected pregnancy. 3. At risk of the development of unwanted pregnancy within the past 72 hours. 4. Known, suspected, or history of cardiovascular, metabolic, or musculoskeletal disease. 5. Undiagnosed abnormal vaginal bleeding. 6. Use of anti-HIV drugs, anticonvulsant drugs, antibiotics, rifampicin/rifabutin, ulipristal acetate, Griseofulvin, Hypericum perforatum (St John's wort) or any other drug that may interfere with the normal pharmacokinetic or pharmacodynamic characteristics of the study intervention. 7. Active or history of migraine. 8. A condition or factor that would prevent the use of Plan B®.

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Conditions

The condition(s) this trial relates to.

Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Female Premenopausal

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vascular Dynamics Lab

    RECRUITING

    Hamilton, Ontario, L8S 4L8, Canada

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