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Scientists probe genetic roots of Cold-Triggered hives

NCT ID NCT00887939

Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why some people develop hives from physical triggers like cold, pressure, or sunlight. Researchers will test participants' skin reactions and collect blood and genetic samples to understand the role of immune cells and genes. The goal is to uncover the underlying causes of these conditions, which could lead to safer and more effective treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal why some people get hives from physical triggers like cold or pressure, pointing toward better treatments.
What could go wrong
This is an observational study, not a treatment trial. It may not lead directly to new therapies, and results may not apply to all types of hives.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

173 people

The number who actually took part.

Started

Jun 2009

Finished

Jun 2024

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Primary clinical

Ages

2 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: Affected subjects/guardian must: 1. Be at least 2 years of age and no older than 90 years of age 2. Have a history of a physical urticaria, which has been evaluated by the patient's healthcare practitioner. 3. Provide copies of pertinent medical records and laboratory studies 4. Have a health care provider outside of NIH 5. Be willing to give informed consent 6. Be willing to donate blood for sample storage to be used for future research Non-affected relatives/guardian must: 1. Be at least 2 years of age and no older than 90 years of age 2. Have a relative who is enrolled on this protocol and is known to have a documented history of a physical urticaria 3. Not have a history of physical urticaria 4. Be willing to give informed consent 5. Be willing to donate blood for sample storage to be used for future research Healthy volunteers must: 1. Be 18-65 years of age 2. Be non-atopic (not have a history of allergic rhinitis, asthma, atopic dermatitis) per subject medical history 3. Have the ability to give informed consent 4. Be willing to donate blood for sample storage to be used for future research 5. Not have a history of physical urticaria EXCLUSION CRITERIA: The following criteria apply to all subjects: 1. Presence of conditions which, in the judgment of the investigator or the referring physician, may put the subject at undue risk, such as acute infection, severe thrombocytopenia (minimum platelet count of 30,000), or significant cardiovascular disease 2. Any condition that in the view of the principal investigator (PI) would make the subject unsuitable for enrollment in this study 3. History of HIV or other known immunodeficiency 4. History or evidence of chronic Hepatitis B and/or C infection 5. Pregnancy

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Conditions

The condition(s) this trial relates to.

autoinflammatory syndrome cryopyrin-associated periodic syndrome familial cold autoinflammatory syndrome familial dermatographia Hypersensitivity, Immediate IgE responsiveness, atopic physical urticaria urticaria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autoinflammatory syndromes Familial cold autoinflammatory syndrome Hypersensitivity, immediate Physical urticaria

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.