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Bed cycling may stop muscle wasting in critically ill patients

NCT ID NCT07017517

Knowledge-focused Sponsor: University of Chile Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding servo-assisted bed cycling to standard physical therapy can reduce muscle breakdown in critically ill patients with sepsis. Researchers will measure inflammation and muscle damage markers in 24 participants over 7 days. The goal is to understand if physical therapy can calm a specific inflammatory pathway (NLRP3) and prevent critical illness myopathy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
servo-assisted cycling device (Motomed Letto®) and standard physiotherapy
What this could lead to
If it works, this could point toward a simple, drug-free way to prevent severe muscle loss in ICU patients.
What could go wrong
This is a very small, early-stage study (24 people) focused on biological markers, not yet on patient outcomes. The results may not lead to a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Medical diagnosis of sepsis upon ICU admission. * Receiving invasive mechanical ventilation with a projected requirement ≥7 days. * SOFA score ≥8 for three consecutive days within the first five days of ICU admission. Exclusion Criteria: * Neurocritical illness. * Prior malnutrition or cachexia. * Pre-existing neuromuscular disease. * Coagulopathy (severe liver disease or continuous dialysis). * Thrombocytopenia \<20,000 platelets/μL. * Prior Clinical Frailty Scale ≥4. * Lower limb amputation or fractures. * Ongoing chemotherapy. * Pregnancy. * BMI \>35. * Uncontrolled epilepsy. * Allergy to ultrasound gel. * Prior prolonged corticosteroid therapy. * Expected ICU stay \<7 days. * Imminent death. * Legal guardian refusal to provide informed consent.

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Conditions

The condition(s) this trial relates to.

acute quadriplegic myopathy muscular atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness myopathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clínica INDISA

    RECRUITING

    Santiago, Metropolitan Region, 7520440, Chile

  • Hospital de Urgencia Asistencia Pública (HUAP)

    RECRUITING

    Santiago, Metropolitan Region, 8330075, Chile

  • University of Chile

    RECRUITING

    Santiago, Metropolitan Region, 8380453, Chile

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