Can physical therapy ease arm pain after breast cancer surgery?
NCT ID NCT04225572
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether physical therapy can help breast cancer patients who develop axillary web syndrome (a condition causing tight, painful cords under the arm) after surgery. Researchers will compare patients who receive physical therapy to those who don't, measuring improvements in movement, pain, and lymphedema. The study involves 135 participants and is already completed.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- physical therapy (exercise, manual therapy, lymphedema treatment)
- What this could lead to
- If it works, this could provide a standard physical therapy approach to help breast cancer patients recover better after surgery.
- What could go wrong
- This is a small, early-stage trial with only 44 participants in the randomized phase, so results may not apply to everyone. Physical therapy is generally low-risk but may not significantly improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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135 people
The number who actually took part.
- Started
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Dec 2017
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 * Patients (female or male) with a tissue diagnosis of non-invasive or invasive breast cancer * Planned surgical breast cancer treatment (lumpectomy or mastectomy) with a minimum removal of one axillary lymph node by sentinel node biopsy. Contralateral prophylactic mastectomy or bilateral mastectomy is allowed. * Voluntary written consent signed before performance of any study-related procedure not part of normal medical care Exclusion Criteria: * Patients (patients unable to travel easily to the University of Minnesota Medical Center for post-surgery visits). * Synchronous bilateral breast cancer * Presence of a medical complication that would prevent the patient from being able to participate in the study, such as terminal cancer * Previous history of upper extremity deep vein thrombosis * Breast cancer surgery without lymph node removal
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Minnesota Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States
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