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Laser light may soothe brace pain without drugs

NCT ID NCT05924204

Symptom relief Sponsor: University of Nove de Julho Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether photobiomodulation—a type of low-level laser therapy—can reduce pain 24 hours after orthodontic spacers are placed. Twenty-five people aged 13 to 30 who need braces will receive the laser on one side of the mouth and a sham treatment on the other. Pain levels, temperature, and quality of life will be measured over three days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
photobiomodulation (low-level laser therapy)
What this could lead to
If effective, this could offer a drug-free way to ease pain after orthodontic spacer placement.
What could go wrong
This is a small, early-stage trial with only 25 participants. The ideal laser protocol is not yet established, and results may not apply to other types of dental pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Mar 2024

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients will include: * With the need to place bilateral orthodontic bands on the lower first molars. * Age 13 to 30 years old. * Both sexes. * No comorbidities. * Never used orthodontic appliances. * Preserved surrounding spaces. * Healthy permanent dentition with good hygiene. Exclusion Criteria: * Patients will be excluded: * Who are taking drugs that affect bone metabolism and the inflammatory process (for example corticosteroids, bisphosphonates), who have used anti-inflammatory drugs or analgesics for less than 1 week since placing elastomeric separators. * Present general pathologies (craniofacial anomalies) and local ones (dental anomalies) that affect the result of the movement of the teeth, * Smokers, embarrassed, or breastfeeding women. * Allergic to paracetamol® * During the investigation, another different drug was used, which was made available by the investigators, and the patient was informed about this alteration.

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Conditions

The condition(s) this trial relates to.

Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inflammation

Contacts and locations

Locations

  • Anna Carolina R.T. Horliana

    São Paulo, São Paulo, 11030-480, Brazil

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