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Does getting older change how your body handles phosphate?

NCT ID NCT07149337

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how age and sex influence the body's ability to manage phosphate after a single oral dose. Forty healthy volunteers in two age groups (18-25 and 63-70) will ingest 558 mg of phosphorus, and researchers will measure phosphate levels in the blood over time. The goal is to understand if kidney function decline with age affects phosphate balance, which could inform future dietary guidelines.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oral phosphate load (558 mg phosphorus)
What this could lead to
If successful, this could help understand why older adults handle phosphate differently, potentially guiding future dietary recommendations for kidney health.
What could go wrong
This is a small, early-stage observational study with only 40 participants, so results may not apply broadly. It does not test a treatment or provide direct health benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2025

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteers 18-25 and 63-70 years old * 18.5 ≥ BMI \< 26 kg/m2 * 0.84 ≥ phosphate in plasma ≤ 1.45 mM * 2.20 ≥ calcium in plasma ≤ 2.50 mM * 15 ≥ PTH in plasma ≤ 65 pg/ml * eGFR ≥ 60 ml/min/1-73 m2 * 90 ≥ Systolic blood pressure ≤ 140 mmHg * 60 ≥ Diastolic blood pressure ≤ 85 mmHg * No hematuria and no acute urinary tract infection * Ability and willingness to participate in the study * Voluntary signed inform consent Exclusion Criteria: * Diabetes mellitus * Pregnancy * History of kidney stones * History of parathyroidectomy * History of anorexia nervosa * History of bulimia * History of solid organ transplantation. * Nephrolithiasis * Sarcoidosis * Chronic pancreatitis * Chronic diarrhea * Chronic liver disease * Complete distal renal acidosis (dRTA) * Cystinuria * Hypo- or hyperaldosteronism * Hyper- or hypotension * Hypernatremia * Gastrointestinal disorders * Known hypersensitivity reactions to azoic dyes, acetylsalicylic acid, as well as antirheumatic drugs and painkillers (prostaglandin synthesis inhibitors). Intake of vitamin D and calcium supplements, phosphate, bisphosphonates, cinacalcet, denusomab, teriparatide, systemic glucocorticoids or mineralcorticoids, antiepileptics, carboanydrase inhibitors or diuretics

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Conditions

The condition(s) this trial relates to.

impaired renal function disease kidney disorder mineral metabolism disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Kidney disease Mineral metabolism

How to take part

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  1. The official record

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More trials for these conditions

Other studies related to the condition(s) this trial covers.