Could a Weight-Loss pill help teens with type 2 diabetes?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ages 12 to \</= 20 years at study entry * Obesity (BMI \>/= the 95th percentile for age and sex) * HgbA1c \>/= 6.5% at type 2 diabetes diagnosis * Negative diabetes auto-antibodies * English-speaking and Spanish speaking * For participants of child-bearing potential: when sexually active, agreement to use two forms of highly effective contraception (oral contraceptive pill, IUD, implant, and/or condoms) during study participation Exclusion Criteria: * Pregnancy or lactation * Newly-initiated or change in dose of weight altering medication within past 6 months, including SGLT-2 inhibitors and DPP-IV inhibitors, liraglutide 1.8 mg and exenatide ER. * Current or recent (\< six months prior to enrollment) use of anti-obesity medication(s) defined as orlistat, phentermine, topiramate, combination PHN/TPM, semaglutide, and/or combination naltrexone/bupropion (monotherapy use of naltrexone or bupropion is not an exclusion) * Current use of sulfonylureas * Previous metabolic/bariatric surgery * Current use of a stimulant medication * History of glaucoma * Current or recent (\< 14 days) use of monoamine oxidase inhibitor or carbonic anhydrase inhibitors * Known hypersensitivity to sympathomimetic amines * Any history of treatment with growth hormone * any history of bulimia nervosa * Major psychiatric disorder as determined by the local medical monitor * Unstable and clinically-diagnosed (defined as documented in the medical record, if available) depression or PHQ-9 score of \>/= 15 * Any history of active suicide attempt, a "yes" answer to Question 4 (Active Suicidal Ideation with Some Intent to Act, Without Specific Plan) on the "Suicidal Ideation" portion of the C-SSR, or a "yes" to answer to Question 5 (Active Suicidal Ideation with Specific Plan and Intent) on the "Suicidal Ideation" portion of the C-SSRS * History of suicidal ideation or self-harm within the previous 30 days or a "yes" answer to any of the suicide-related behaviors (actual attempt, interrupted attempt, aborted attempt, preparatory act, or behavior) on the "Suicidal Behavior" portion of the C-SSRS and the ideation or behavior occurred within the past month. * Current pregnancy or plans to become pregnant during study participation * Current tobacco use * ALT or AST \>/= 3 times the upper limit of normal * Moderate (Child-Pugh score 7-9) or severe (Child-Pugh score 10-15) * Bicarbonate \<18 mmol/L * Moderate (creatinine clearance \[CrCl\] greater than or equal to 30 and less than 50 mL/min) or severe (CrCl less than 30 mL/min) renal impairment * Any history of seizures • BP for ages 13 and older of \> 130/80 on 3 separate measurements and for age 12 \> 95th percentile on 3 separate measurements * HR ≥120 bpm on 3 separate measurements * History of structural heart defect or clinically significant arrhythmia * Diagnosed monogenic obesity * Any history of cholelithiasis * Any history of nephrolithiasis * Clinically diagnosed hyperthyroidism * Untreated thyroid disorder or TSH below the lower laboratory limit of normal * Any disorder, unwillingness, or inability, not covered by any other exclusion criteria, which in the investigator's opinion may put the participant at risk