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Can a simple DNA test make medications safer for seniors?

NCT ID NCT05091879

Knowledge-focused Sponsor: Geisinger Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a DNA test (pharmacogenomics) could help doctors choose the right medications for older adults taking five or more drugs. Researchers tested 66 participants and measured how often the results led to medication changes. The goal was to see if this approach could improve safety and lower healthcare costs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Multigene pharmacogenomics test (DNA test)
What this could lead to
If successful, this approach could help doctors choose safer, more effective medications for older adults based on their genetic makeup.
What could go wrong
This is a small, completed study (66 participants) focused on feasibility, not on proving health outcomes. Results may not apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

66 people

The number who actually took part.

Started

Mar 2023

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Follows at a Geisinger 65 Forward clinic location * Active prescriptions for 5 or more medications Exclusion Criteria: * Liver transplantation * Allogenic hematopoetic stem cell transplantation * Previously enrolled in the Electronic Medical Records and Genomics (eMERGE) pharmacogenomics cohort

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pharmacogenomic testing Polypharmacy

Contacts and locations

Locations

  • Geisinger

    Danville, Pennsylvania, 17822, United States

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