New Opioid-Like drug aims to ease Post-Surgery pain
NCT ID NCT06602271
First seen Jan 06, 2026 · Last updated Jun 19, 2026 · Updated 36 times
Summary
This Phase 3 trial tests PF614, a new extended-release painkiller related to oxycodone, in 320 people recovering from tummy tuck surgery. Participants receive either the drug or a placebo before surgery and every 12 hours for up to 4 days. The study measures pain relief and safety, with a focus on reducing the need for extra rescue pain medication.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CenExel / Atlanta Center for Medical Research (ACMR)
RECRUITINGAtlanta, Georgia, 30331, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CenExel / JBR
RECRUITINGSalt Lake City, Utah, 84107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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HD Research - Memorial Hermann Surgery Center
RECRUITINGHouston, Texas, 77043, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PF614 (an extended-release oxycodone prodrug)
What this could lead to
If it works, this could provide a new painkiller option for people recovering from surgery, with possibly fewer side effects than standard opioids.
What could go wrong
This is a Phase 3 trial, but it only tests pain after one type of surgery. The drug may not work better than placebo, and like all opioids, it carries risks of side effects and dependence.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.