POSTOPERATIVE PAIN, ACUTE

This study tests whether injecting the painkiller ketorolac into a leg during surgery can reduce pain after the operation. 76 adults having lower leg surgery with a tourniquet will receive either ketorolac or a saltwater solution. The main goal is to see how long pain relief last…

This study tests whether a special nerve block (EOI block) can reduce pain and the need for strong painkillers in teenagers having ear reconstruction surgery using rib cartilage. Sixty participants aged 13 to 18 will be randomly assigned to receive either the nerve block or stand…

This study looks at whether giving the painkiller nalbuphine at different times during knee replacement surgery can better control pain and keep the heart stable in patients aged 65 and older. About 162 participants will receive nalbuphine either during anesthesia or after cement…

This Phase 3 trial tests PF614, a new extended-release painkiller related to oxycodone, in 320 people recovering from tummy tuck surgery. Participants receive either the drug or a placebo before surgery and every 12 hours for up to 4 days. The study measures pain relief and safet…

This study looks at whether a single dose of meloxicam (a different anti-inflammatory) can control pain better than the usual ibuprofen after Mohs surgery for skin cancer. About 300 adults will be split into three groups, each getting a different pain medicine routine. They will …

This study looks at whether starting a supervised walking program soon after obesity surgery, and continuing it at home, can help manage pain and speed up recovery. Researchers will track pain levels, physical function, and quality of life in 112 participants. The goal is to find…

This study compares a long-acting painkiller (liposomal bupivacaine) to a standard one for pain after lung surgery. About 210 adults having keyhole lung surgery will be randomly assigned to receive one of the two painkillers or no nerve block. The goal is to see if the long-actin…

This study tests if a specific nerve block (SPSIP block) can reduce pain after arthroscopic shoulder surgery. About 80 adults having elective shoulder surgery will receive this block or standard care. The main goal is to see if it lowers the amount of opioid pain medicine needed …

This study is testing whether a special nerve block (PENG block) given before hip replacement surgery can help reduce pain, lower the need for strong painkillers, and help patients get moving sooner. About 60 adults aged 40-85 who are having hip replacement will take part. The go…

This study aims to find the most effective dose of morphine given into the spinal fluid to control pain after a C-section. Researchers will test different doses in 100 healthy women having planned C-sections, adjusting the dose based on how well the previous participant's pain wa…

This study compares two ways to block pain during lung surgery (VATS) to see if they can prevent chronic pain that lasts for months. Forty adults having planned lung surgery will receive either an ultrasound-guided nerve block or a surgeon-given block. Researchers will track pain…