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Can PET-MRI spot hidden brain tumors in kids?

NCT ID NCT05553899

Knowledge-focused Sponsor: Sheffield Children's NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether a combined PET-MRI scan can better detect if a child's brain tumor has returned after treatment. The study will include 5 children with high-grade gliomas or medulloblastomas who have unclear results from standard MRI. The main goal is to see if such a study is feasible, not yet to prove the method works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PET-MRI with 18F-FDG tracer
What this could lead to
If successful, this could show that PET-MRI is a better way to spot tumor recurrence in children, potentially improving follow-up care.
What could go wrong
This is a very small pilot study with only 5 participants, so results may not apply widely. It is testing feasibility, not effectiveness, and may not lead to changes in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 5 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a presumptive or histologically confirmed diagnosis of a malignant brain tumour requiring treatment * Diagnostic uncertainty about tumour recurrence post-treatment based on conventional MR imaging in the opinion of the MDT * Have a life expectancy of at least three months * Able to comply with an MRI scan without a general anaesthetic Exclusion Criteria: * Unable to comply with an MRI scan without a general anaesthetic * Diabetes or other causes of hyperglycaemia * Pregnancy * Patient body habitus above scanner dimensions * Standard contra-indication to MRI (eg. pacemaker, non-compatible metallic implants, altered renal function)

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Conditions

The condition(s) this trial relates to.

brain cancer malignant glioma medulloblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain tumor, pediatric

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sheffield Children's Hospital

    RECRUITING

    Sheffield, South Yorkshire, S10 1SN, United Kingdom

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