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Pesticides may harm egg quality, IVF study suggests

NCT ID NCT03647020

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether exposure to pesticides affects the quality of a woman's eggs and the success of IVF. Researchers analyzed data from 633 women in France who underwent a specific type of IVF (ICSI). They compared women with a high number of eggs showing a certain abnormality (CLCG) to those with a low number. The goal was to see if this abnormality was linked to pesticide exposure and worse IVF outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the link is confirmed, it could lead to better advice for women trying to conceive who live in farming areas.
What could go wrong
This is a retrospective study, so it can only show a connection, not prove cause and effect. The results may not apply to other regions or populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

633 people

The number who actually took part.

Started

Jan 2011

Finished

Jun 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The population in the retrospective study consisted of 633 couples who attended a reproductive medical center and who were part of an ICSI program between 2009 and 2011. The study population is described in Table 1\. In the selected couples, women were normo-responders (oocyte cohort over 5), under 35 years old, living in the Picardy, France region, and exhibited CLCG after oocyte morphology evaluation which was confirmed by a second embryologist (Fig. 1

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * couples who attendes a reproductive medical center * couples that were part of a ICSI program between 2009 and 2011 * women were normo-responders * female \> 18 years \<35 yeas old Exclusion Criteria: * female \< 18 years \> 35 yeas old * couple with severe male infertility factors on oocyte activation and subsequent embryo development

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pesticide poisoning

Contacts and locations

Locations

  • CHU Amiens-Picardie

    Amiens, 80054, France

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