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Custom breathing plans may cut ICU ventilator time

NCT ID NCT05719194

Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a personalized approach to removing breathing tubes in the ICU works better than standard care. About 691 adults on ventilators for over 24 hours were included. Doctors used daily checks and chose the best method (T-piece or pressure support) based on each patient's risk factors like obesity or heart disease. The goal was to see if this strategy improves survival, reduces the need for re-intubation, and shortens time on the ventilator.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

691 people

The number who actually took part.

Started

Mar 2023

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria : all patients ≥ 18 y.o admitted to the ICU, under invasive mechanical ventilation for more then 24 hours and fullfilling the following weaning criteria : * Resolution or improvement of the condition that led to intubation, as judged by the clinician in charge of the patient. * Hemodynamic stability, defined as systolic blood pressure between 90 and 160 mmHg, heart rate less than 140 beats/min, without or with low doses of vasopressors. * Glasgow score of 13 or greater and Richmond Agitation-Sedation Scale (RASS) score between -1 and +1. * Respiratory stability defined as: oxygen saturation \> 90% with inspired oxygen fraction ≤ 0.5 and PEEP ≤ 8 cmH2O, respiratory rate \< 35/min, spontaneous tidal volume \> 5 mL/kg, and peak inspiratory pressure ≤ 15 cmH2O. * Few secretions (\< 3 aspirations in the past 8 hours). * Effective cough. * Negative leak test (\>100 mL or \>10%). * No surgery planned within 72 hours. * Patients with a social security plan. Exclusion Criteria: * Acute cerebral pathology requiring admission to intensive care and/or mechanical ventilation with tracheal intubation for neurological reasons (Glasgow score \<13 at the time of intubation or CT scan abnormality): hemorrhagic stroke without or with vascular malformation (aneurysm, arterio-venous malformation...), ischemic stroke, head trauma, cerebral anoxo-ischemia after cardiac arrest. * Tetraplegic or paraplegic patients with lesion level higher than D8. * Peripheral neuromuscular pathology (underlying myopathy or myasthenia). * ICU's Neuromyopathy. * Tracheostomy. * Patients with a decision of non-reintubation or terminal intubation. * Pregnant or lactating women. * Patients already included in this study. * Patients under guardianship, curatorship or safeguard of justice.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intubation Mechanical ventilation Weaning

Contacts and locations

Locations

  • CHU de Bordeaux

    Bordeaux, France

  • CHU de Clermont-Ferrand

    Clermont-Ferrand, France

  • CHU de Grenoble

    Grenoble, France

  • CHU de Lille

    Lille, France

  • CHU de Lyon - Hôpital Lyon Sud

    Lyon, France

  • CHU de Montpellier

    Montpellier, France

  • CHU de Nantes

    Nantes, France

  • CHU de Saint-Etienne

    Saint-Etienne, France

  • CHU de Toulouse

    Toulouse, France

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