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Can personalized sound waves boost brain health in dementia?

NCT ID NCT07778277

Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial explores whether a personalized system that combines gamma-frequency sound stimulation with cognitive training can improve thinking and memory in older adults with mild cognitive impairment or early dementia. Participants aged 60 and older will use the device during cognitive activities for one hour, twice a week, over 12 weeks. The study aims to see if this approach is practical and effective in both urban and rural dementia care centers, potentially offering a new way to support brain health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Personalized gamma auditory stimulation device (active setting) combined with cognitive training
What this could lead to
If effective, this approach could offer a non-invasive, personalized way to support brain health and slow cognitive decline in people with early dementia, potentially adaptable across urban and rural care centers.
What could go wrong
This is a small, early-stage feasibility study, so results may not be conclusive or widely applicable. The intervention requires regular sessions, and individual responses may vary; there is also a risk that the stimulation may not produce meaningful cognitive benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged ≥ 60 years * The score of MoCA between 10 to 25 Exclusion Criteria: * Diagnosis of other psychiatric or neurological disorders, and those with a history of neurological or psychiatric disorders that may affect cognitive assessment or performance. For example (but not limited to): Parkinson's disease, schizophrenia, major depressive disorder, epilepsy, severe traumatic brain injury with loss of consciousness, and stroke. * Drug, Nicotine or alcohol addictions * Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.

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Conditions

The condition(s) this trial relates to.

dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acoustic stimulation Cognitive training Dementia Healthcare disparities Precision medicine

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chang Gung University

    Taoyuan, Guishan, 333, Taiwan

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