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Can vitamins boost gum bone healing? new study tests simple addition to standard treatment

NCT ID NCT05499598

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding vitamins A and C to a platelet-rich fibrin (PRF) treatment helps repair bone defects in the gums. Twenty-eight adults with advanced gum disease received a minimally invasive surgical technique with PRF, with or without the vitamins. The goal was to see if the vitamin mix improves bone fill and gum attachment over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich fibrin with vitamins A and C
What this could lead to
If it works, this could offer a better way to repair gum bone damage and improve dental health without major surgery.
What could go wrong
This is a small, early-stage trial with only 28 participants, so results may not apply to everyone. Adding vitamins may not provide extra benefit over standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28 people

The number who actually took part.

Started

Sep 2022

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient-related criteria: * Patient consulting in the outpatient clinic with periodontitis stage III * Able to tolerate surgical periodontal procedures. * Patient ready to perform oral hygiene instructions. * Compliance with the maintenance program. * Provide informed consent. * Accepts the 6 months follow-up period. Teeth related criteria: * Mature permanent tooth. * Tooth with two or three-walled intra-bony defect, with CAL ≥ 5mm and intra osseous defect ≥ 3mm. Exclusion Criteria: * Patient-related criteria: * Medically compromised patients. * Pregnant or nursing women. * Uncooperative patients. * Smokers. Teeth related criteria: * Teeth with one wall intra-bony defect. * Teeth with supra-bony defects. * Teeth with grade III mobility.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intrabony periodontal defect

Contacts and locations

Locations

  • Cairo University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.