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Could peppermint oil mouthwash soothe chemo nausea?

NCT ID NCT07179094

Symptom relief Sponsor: Şule Güzle Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a peppermint oil mouthwash can help reduce nausea, vomiting, and loss of appetite caused by chemotherapy in people with blood cancers. 72 patients will be split into two groups: one gets standard oral care, the other rinses with peppermint oil three times daily for six days after chemo. Researchers will track symptoms and oral health to see if the peppermint rinse makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
peppermint oil mouthwash
What this could lead to
If it works, this could offer a simple, natural way to reduce nausea, vomiting, and appetite loss during chemotherapy for blood cancer patients.
What could go wrong
This is a small, early-stage trial with only 72 people. Peppermint oil may cause allergic reactions or not work better than standard care. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2025

An estimate. Start dates often move.

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Clinical diagnosis of hematologic malignancy * History of at least one chemotherapy cycle * Scheduled to receive chemotherapy with high or moderate emetogenic risk agents * No oral mucositis before chemotherapy * No metastasis * Literate (able to read and write) * Volunteer to participate in the study Exclusion Criteria: * Use of herbal remedies for nausea, vomiting, or anorexia * Concurrent radiotherapy with chemotherapy * Non-adherence to standard antiemetic therapy according to the chemotherapy preparation regimen and protocol (e.g., use of antiemetics other than granisetron or metoclopramide) * Known allergy to peppermint oil * Psychiatric disorders * Communication impairments (hearing or speech difficulties) * Altered level of consciousness * Endotracheal intubation * Requirement for oral care solutions other than the clinic's routine procedures (saline or sodium bicarbonate) * Chronic gastrointestinal diseases (gastritis, gastric/peptic ulcer, ulcerative colitis, Crohn's disease, gastroesophageal reflux, irritable bowel syndrome, cirrhosis, or pancreatitis) * Migraine * Brain metastases * Hepatic or renal insufficiency * Administration of low-emetogenic chemotherapy * Mucositis (Oral Assessment Guide score: 15-24 points)

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Conditions

The condition(s) this trial relates to.

Anorexia anorexia nervosa hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm Nausea Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anorexia Hematologic neoplasms Nausea Vomiting

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.