HEMATOLOGIC NEOPLASMS

This study compares three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma. The goal is to see which vaccine triggers the strongest immune response in people with weakened immune systems. Participants will receive one of the vaccines and have their…

This study tests whether a drug called tranexamic acid can safely replace routine platelet transfusions in adults receiving a stem cell transplant for blood cancers. About 662 participants will either get tranexamic acid or standard platelet transfusions. The goal is to see if th…

This early-stage study is testing an experimental drug called JNJ-95804306 in people with blood cancers (like leukemia) that have returned or not improved after standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors…

This study tests whether red blood cells stored with less oxygen (hypoxic RBCs) are safer and more effective than standard transfusions for people with blood cancers who need regular blood. About 24 adults with transfusion-dependent blood cancers will receive both types of blood …

This study tests an experimental drug, KK2430, for the first time in people with blood cancers. The main goals are to check if the drug is safe, how the body handles it, and whether it can help treat the disease. About 72 adults with measurable tumors will take part.

This study tests whether giving donor white blood cells (lymphocytes) soon after a stem cell transplant can lower the chance of cancer returning in people with high-risk blood cancers like leukemia or lymphoma. Participants receive chemotherapy, a stem cell transplant, and then a…

This study tests a new approach for people with aggressive blood cancers that have not responded well to standard treatments. It combines two powerful therapies: a half-matched bone marrow transplant and specially engineered CAR T-cells that target a protein called CD19 on cancer…

This study is for adults aged 18-85 with blood cancers that haven't responded well to standard treatments. It tests whether a lower dose of the drug cyclophosphamide, given after a bone marrow transplant, can reduce side effects while still preventing graft-versus-host disease (a…

This study tests whether a computer brain-training program (Lumosity) can improve memory and thinking in adults who had a stem cell transplant for blood cancer. About 60 survivors, 3 to 6 months after transplant, will either start training right away or wait 12 weeks. The goal is…

This study tests whether a mind-body group program can help reduce fatigue in people who have finished treatment for blood cancers like leukemia or lymphoma. About 94 participants who are in remission will be randomly assigned to the program or usual care. The goal is to see if t…

This study looks at how cancer affects not just patients, but their entire family. Researchers will survey 240 Danish patients with breast, prostate, colorectal cancer, or lymphoma, along with their caregivers. They aim to understand family health, needs, and support over time, a…

This study enrolls up to 10,000 adults with cancer to see how a special team of experts (a molecular tumor board) uses genetic testing to recommend personalized treatments. Researchers will track whether doctors follow these recommendations and if patients benefit. The goal is to…

This study tests whether using artificial intelligence (AI) to rewrite medical discharge letters into plain language helps cancer patients better understand their diagnosis, treatment, and next steps. About 150 adults with blood cancer or other cancers will be randomly assigned t…

This study is looking at 2,000 people who have early warning signs of blood cancers or bone marrow failure. Researchers use a special genetic test (next generation sequencing) to find changes in cancer-related genes. The goal is to better understand who is at risk and to catch th…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with cancer or blood disorders, as well as from healthy family members who are stem cell donors. The samples are used for research to better understand diseases, improve treatments, and find…