Digital tool helps doctors pick safer antibiotics for penicillin allergy patients
NCT ID NCT07604597
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a digital decision support tool for doctors treating hospitalized patients who report a penicillin allergy. Most people who think they are allergic to penicillin are not actually allergic, but they often receive less effective antibiotics. The tool helps doctors assess allergy risk and choose the best antibiotic according to hospital guidelines. The study included 182 adults and aimed to see if the tool increased the use of penicillin-type antibiotics.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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182 people
The number who actually took part.
- Started
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Sep 2025
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of hospitalized adult patients (aged 16 years or older) treated for infections requiring systemic antibiotic therapy, who have a documented or self-reported penicillin allergy. Participants are identified in a tertiary care hospital setting and include both patients treated before and after the implementation of a digital clinical decision support tool integrated into the electronic medical record.
- Ages
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16 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 16 years * Hospitalized patients * Diagnosis of infection requiring systemic antibiotic therapy * Documented penicillin and/or cephalosporin allergy in the electronic medical record or self-reported allergy during current admission * For the retrospective cohort: patients previously admitted to hospital or emergency department (≥16 hours) with a recorded penicillin allergy label * Ability to understand study information and provision of written informed consent (prospective cohort only) Exclusion Criteria: * Patients with a reported penicillin allergy who do not require systemic antibiotic treatment * Patients admitted to intensive care or intermediate care units * Patients receiving outpatient hospital care or dialysis units * Patients in end-of-life care or receiving palliative care * Patients receiving antibiotics for surgical prophylaxis only
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital Sant Joan de Déu - Althaia
Manresa, Barcelona, 08243, Spain
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