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PCOS brain scans reveal hidden clues

NCT ID NCT03043924

Knowledge-focused Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study used advanced MRI scans to look at the hypothalamus, a brain region that controls hormones, in women with PCOS. Researchers compared 52 women with and without PCOS to see if there were differences in brain structure and chemistry. The goal was to better understand how PCOS affects the brain, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

52 people

The number who actually took part.

Started

Sep 2017

Finished

Apr 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 30 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For all subjects * Aged from 19 to 30 years * Body mass index : 18-25 * Informed consent before inclusion * Do not smoke the 3 days before the MRI For Healthy volunteers subjects : * Regular cycles (between 25 and 35 days) AND ovulatory. * No signs of hyperandrogenism. * Subjects desirous of taking oral contraceptives (estrogen/progestin combination). * For the realization of the 2nd MRI: to be during the 3rd month of a treatment well followed by oestro-progestative monophasic minidose to 0,02mg of Ethinyl-oestradiol / 0,1mg Levonorgestrel. PCOS women: * PCOS defined by Rotterdam criteria * Needing a treatment with cyproterone acetate * To carry out the 2nd MRI: to be in progress during the 3rd month of a treatment well followed by 50 mg of Cyproterone acetate in association with 2mg / day of natural estradiol. Exclusion Criteria: * Hormone treatment within 3 months prior to inclusion (including birth control pill ) * On-going pregnancy (determined before each MRI scan visit) * Claustrophobia * Any metal or foreign implants (e.g., aneurysm clips, ear implants, heart pacemakers or defibrillators) * Diabetes or known dysthyroidism. * Current substance abuse (including smoking more than 5 cigarettes/day; determined using drug screening at the screening visit) * Pregnancy or breastfeeding the last 3 months. * Practice of intense physical exercise (ex jogging\> 10km) the day before the MRI. * Person incapable of consenting, or enjoying legal protection (guardianship / curatorship). * Unability to understand the treatment protocol

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Polycystic ovary syndrome

Contacts and locations

Locations

  • Hôpital Jeanne de Flandres, CHU

    Lille, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.