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Could a hidden infection explain that thickened nuchal translucency?

NCT ID NCT05388968

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether infections might be linked to increased nuchal translucency, a marker seen on early pregnancy ultrasounds. Researchers used advanced genetic sequencing to look for viruses, bacteria, or parasites in placental tissue from 78 pregnant women. The goal was to see if hidden infections could be a cause, but this was an observational study, not a treatment trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could show that some cases of increased nuchal translucency are caused by infections, potentially leading to new screening or treatment approaches.
What could go wrong
This is a small, completed observational study, not a treatment trial. It only looks for infections and does not test any therapy, so it cannot prove cause or offer direct benefit to participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

78 people

The number who actually took part.

Started

Nov 2022

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women consulting in the prenatal diagnosis Unit of the University Hospital Necker-Enfants-malades

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pregnant women * Singleton pregnancy * First trimester (11 GA+0D to 13 GA+6D) * Carrying a fetus with a nuchal translucency \> 3.5 mm for which a chorionic villi sampling is performed OR a suspicion of genetic abnormalities for which a chorionic villi sampling is performed * Delivery planned at Necker hospital * Not opposed to participation Exclusion Criteria * Age \<18 years * no health insurance * difficulties in understanding the French language * chronic infection (HIV, HBV, HVC and HTLV-1)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Increased nuchal translucency in the first trimester of pregnancy

Contacts and locations

Locations

  • Hopital Necker - Enfants malades

    Paris, 75015, France