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Ear stimulation + exercise shows promise for Parkinson's symptoms

NCT ID NCT05871151

Symptom relief Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a gentle electrical stimulation of the vagus nerve through the ear, combined with physical therapy, can help people with Parkinson's disease move better and feel better. Twenty-five adults with Parkinson's who could walk without help took part. The goal was to see if this combination improves walking, balance, and overall quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Oct 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of PD by a board-certified neurologist * age between 35 and 80 years * no walking aids * stable medication 4 weeks prior to and during the study * no falls in the past 6 months * participant must have MD who is willing to provide oversight and approval for clinically defined OFF state Exclusion Criteria: * mild cognitive impairment (MoCA \<25) * self reported depression * antidepressive or antipsychotic medication * participation in a VNS study in the past year * disabling bradykinesia to ensure patients are able to participate in intensive physiotherapy (based on clinical impression and in accordance to UPDRS part III item 14 - to be administered in clinic) * prior history of cardiovascular, neurological or musculoskeletal disorders known to interfere with testing PD features * implanted medical device of any type * history of seizures * peripheral neuropathy including temporal mandibular disorders and Bells Palsy, and * vasovagal syncope.

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Conditions

The condition(s) this trial relates to.

Motor Activity Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

Contacts and locations

Locations

  • UAB

    Birmingham, Alabama, 35233, United States

  • WHARF

    Birmingham, Alabama, 35209, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.