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Treadmill training may slow Parkinson's by fighting inflammation

NCT ID NCT05815524

Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether intensive treadmill exercise can improve motor symptoms and reduce inflammation in people with early-stage Parkinson's disease. Researchers measured changes in movement scores and blood markers of nerve damage and inflammation in 30 patients who either exercised or continued their usual routine. The goal was to see if physical activity could act as a disease-modifying approach, but the study was terminated early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
treadmill training
What this could lead to
If successful, this could point toward physical activity as a way to slow Parkinson's progression by reducing inflammation and supporting brain health.
What could go wrong
The study was terminated early and enrolled only 30 people, so results are limited. It is not a treatment and may not apply to all Parkinson's patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

May 2022

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with PD defined according to MDS criteria * Hoehn \& Yahr Stage 1-3 * Stable dopaminergic therapy in the previous month * Duration of disease of at least 3 years * MMSE \> 24/30 * Age between 45-70 years * Signature of the informed consent to participate in the study in question Exclusion Criteria: * Contraindications to the practice of physical activity as required by the European Society of Cardiology 2020 guidelines * Practice of regular sporting activity for more than 150 minutes per week * Serious orthopedic pathologies * Severe psychiatric disorders * Inflammatory or autoimmune diseases * Active oncological pathologies * Known cardiovascular and/or cardiorespiratory pathologies that may contraindicate or influence the performance of the motor program (ischaemic heart disease, arterial hypertension not under pharmacological treatment, primary or secondary non-Parkinson-related cardiomyopathies and/or valve diseases, channelopathies, anemia, heart failure, COPD pulmonary hypertension, bronchial asthma).

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

Contacts and locations

Locations

  • Flavia Torlizzi

    Roma, 00168, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.