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Surgery may boost bone health in kidney transplant patients with stubborn high calcium

NCT ID NCT07415421

Disease control Sponsor: Aarhus University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares parathyroid surgery to standard monitoring in 85 kidney transplant recipients who still have high calcium and parathyroid hormone levels. The goal is to see if surgery improves bone density, physical function, and quality of life over 12 months. Participants are randomly assigned to either have the surgery or continue with regular check-ups and blood tests.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Subtotal parathyroidectomy (surgery to remove most of the parathyroid glands)
What this could lead to
If surgery proves better than monitoring, it could become a standard option to improve bone health and daily well-being for kidney transplant patients with this condition.
What could go wrong
This is a small pilot trial with only 85 people, so results may not apply to everyone. Surgery carries risks like infection or low calcium levels, and the benefit over conservative care is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 85 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria * Age \> 18 years and legally competent and able to understand spoken and written Danish * Kidney transplantation ≥6 months prior (no upper limit of time after transplantation) * Stable kidney graft function, defined as estimated GFR ≥ 30 ml/min/1.73m3 * On minimum two separate biochemical measurements: PTH \> upper normal limit of assay and * serum ionized calcium ≥1.33 mmol/L or * serum total calcium ≥2.60 mmol/L or * serum phosphate ≤0.60 mmol/L despite sufficient dietary intake with measurements obtained within * 3 months in patients 6-12 months post-transplant * 6 months in patients \>12 months post-transplant and not attributable to calcium supplementation or treatment with thiazide diuretics or lithium. Exclusion criteria * Inability to provide written, informed consent * Current anti-resorptive therapy (bisphosphonate, denosumab) * Current bone anabolic therapy (teriparatide, romosozumab) * Previous surgical parathyroidectomy * Not considered fit for surgery (including pregnancy) * Ionized calcium ≥1.50 mmol/L or albumin-corrected calcium ≥3.00 mmol/L despite discontinuation of calcium supplements.

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Conditions

The condition(s) this trial relates to.

hyperparathyroidism tertiary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hyperparathyroidism Kidney transplantation recipients

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Departement of Nephrology, Aarhus University hospital

    RECRUITING

    Aarhus, Central Jutland, 8200, Denmark

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